000132165 001__ 132165
000132165 005__ 20240301161206.0
000132165 0247_ $$2doi$$a10.3390/diagnostics14050492
000132165 0248_ $$2sideral$$a137410
000132165 037__ $$aART-2024-137410
000132165 041__ $$aeng
000132165 100__ $$aArias-Alvarez, Marta
000132165 245__ $$aRetinal Function in Long-Term Type 1 Diabetes without Retinopathy: Insights from Pattern Electroretinogram and Pattern Visual Evoked Potentials Assessments
000132165 260__ $$c2024
000132165 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132165 5203_ $$aBackground: To evaluate changes in pattern electroretinogram (pERG) and pattern visual evoked potentials (pVEP) in patients with long-lasting type 1 diabetes without diabetic retinopathy (DR). Methods: Prospective study involving 92 eyes divided into two groups. The diabetic group included 46 eyes of 23 patients with type 1 diabetes (T1DM); the control group included 23 age-matched healthy subjects. pERG and pVEP were assessed using the RETI-port/scan21 recording software (version 1021.3.0.0). Results: Mean age was 48 ± 9.77 years for the diabetic group and 51.7 ± 4.75 years for the control group. The mean duration of diabetes was 28.88 ± 8.04 years. The mean HbA1c value was 7.29 ± 0.89%. There were no differences in the age or sex distribution. Regarding the pERG, T1DM patients exhibited a significant decrease in the amplitude of the P50 and N95 waves compared to the control group (p = 0.018 and p = 0.035, respectively), with no differences in the peak time of each component. pVEP showed no significant changes in either peak time or amplitude of the different components. Conclusions: Long-term T1DM patients without DR showed changes in the amplitude of pERG waves with preserved peak times. We did not observe modifications in pVEP. pERG may serve as a subclinical marker of ganglion cell damage in long-term T1DM patients.
000132165 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740
000132165 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132165 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132165 700__ $$aSopeña-Pinilla, Maria
000132165 700__ $$0(orcid)0000-0003-1234-9712$$aFernandez-Espinosa, Guisela
000132165 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000132165 700__ $$aVicente-Garza, Ines
000132165 700__ $$aBonet-Rodriguez, Anna
000132165 700__ $$0(orcid)0000-0002-2987-6351$$aAcha-Perez, Javier
000132165 700__ $$aRodriguez-Mena, Diego$$uUniversidad de Zaragoza
000132165 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000132165 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000132165 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000132165 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000132165 773__ $$g14, 5 (2024), 492 [11 pp.]$$tDiagnostics$$x2075-4418
000132165 8564_ $$s615954$$uhttps://zaguan.unizar.es/record/132165/files/texto_completo.pdf$$yVersión publicada
000132165 8564_ $$s2710694$$uhttps://zaguan.unizar.es/record/132165/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132165 909CO $$ooai:zaguan.unizar.es:132165$$particulos$$pdriver
000132165 951__ $$a2024-03-01-14:51:02
000132165 980__ $$aARTICLE