Retinal Function in Long-Term Type 1 Diabetes without Retinopathy: Insights from Pattern Electroretinogram and Pattern Visual Evoked Potentials Assessments

Arias-Alvarez, Marta ; Sopeña-Pinilla, Maria ; Fernandez-Espinosa, Guisela ; Orduna-Hospital, Elvira (Universidad de Zaragoza) ; Vicente-Garza, Ines ; Bonet-Rodriguez, Anna ; Acha-Perez, Javier ; Rodriguez-Mena, Diego (Universidad de Zaragoza) ; Pinilla, Isabel (Universidad de Zaragoza)

Resumen: Background: To evaluate changes in pattern electroretinogram (pERG) and pattern visual evoked potentials (pVEP) in patients with long-lasting type 1 diabetes without diabetic retinopathy (DR). Methods: Prospective study involving 92 eyes divided into two groups. The diabetic group included 46 eyes of 23 patients with type 1 diabetes (T1DM); the control group included 23 age-matched healthy subjects. pERG and pVEP were assessed using the RETI-port/scan21 recording software (version 1021.3.0.0). Results: Mean age was 48 ± 9.77 years for the diabetic group and 51.7 ± 4.75 years for the control group. The mean duration of diabetes was 28.88 ± 8.04 years. The mean HbA1c value was 7.29 ± 0.89%. There were no differences in the age or sex distribution. Regarding the pERG, T1DM patients exhibited a significant decrease in the amplitude of the P50 and N95 waves compared to the control group (p = 0.018 and p = 0.035, respectively), with no differences in the peak time of each component. pVEP showed no significant changes in either peak time or amplitude of the different components. Conclusions: Long-term T1DM patients without DR showed changes in the amplitude of pERG waves with preserved peak times. We did not observe modifications in pVEP. pERG may serve as a subclinical marker of ganglion cell damage in long-term T1DM patients.

Idioma: Inglés

DOI: 10.3390/diagnostics14050492

Año: 2024

Publicado en: Diagnostics 14, 5 (2024), 492 [11 pp.]
ISSN: 2075-4418

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)