000132290 001__ 132290
000132290 005__ 20240516094559.0
000132290 0247_ $$2doi$$a10.1016/j.mtbio.2023.100935
000132290 0248_ $$2sideral$$a137403
000132290 037__ $$aART-2023-137403
000132290 041__ $$aeng
000132290 100__ $$aRodrigo, María J.$$uUniversidad de Zaragoza
000132290 245__ $$aLaponite for biomedical applications: An ophthalmological perspective
000132290 260__ $$c2023
000132290 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132290 5203_ $$aClay minerals have been applied in biomedicine for thousands of years. Laponite is a nanostructured synthetic clay with the capacity to retain and progressively release drugs. In recent years there has been a resurgence of interest in Laponite application in various biomedical areas. This is the first paper to review the potential biomedical applications of Laponite in ophthalmology. The introduction briefly covers the physical, chemical, rheological, and biocompatibility features of different routes of administration. After that, emphasis is placed on 1) drug delivery for antibiotics, anti-inflammatories, growth factors, other proteins, and cancer treatment; 2) bleeding prevention or treatment; and 3) tissue engineering through regenerative medicine using scaffolds in intraocular and extraocular tissue. Although most scientific research is not performed on the eye, both the findings and the new treatments resulting from that research are potentially applicable in ophthalmology since many of the drugs used are the same, the tissue evaluated in vitro or in vivo is also present in the eye, and the pathologies treated also occur in the eye. Finally, future prospects for this emerging field are discussed.
000132290 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113281RB-C22$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113281RB-C21$$9info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-2$$9info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-1$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00437$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII/M17-00213$$9info:eu-repo/grantAgreement/ES/ISCIII/JR22-00057
000132290 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132290 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132290 700__ $$0(orcid)0000-0002-7914-4685$$aCardiel, María J.$$uUniversidad de Zaragoza
000132290 700__ $$0(orcid)0000-0002-0136-5138$$aFraile, José M.
000132290 700__ $$0(orcid)0000-0003-1570-4257$$aMayoral, José A.$$uUniversidad de Zaragoza
000132290 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, Luis E.$$uUniversidad de Zaragoza
000132290 700__ $$0(orcid)0000-0001-6258-2489$$aGarcía-Martin, Elena$$uUniversidad de Zaragoza
000132290 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000132290 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000132290 7102_ $$11013$$2020$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Anatomía Patológica
000132290 773__ $$g24 (2023), 100935 [14 pp.]$$tMaterials Today Bio$$x2590-0064
000132290 8564_ $$s4515183$$uhttps://zaguan.unizar.es/record/132290/files/texto_completo.pdf$$yVersión publicada
000132290 8564_ $$s2673324$$uhttps://zaguan.unizar.es/record/132290/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132290 909CO $$ooai:zaguan.unizar.es:132290$$particulos$$pdriver
000132290 951__ $$a2024-05-16-09:33:42
000132290 980__ $$aARTICLE