000133116 001__ 133116
000133116 005__ 20250923084413.0
000133116 0247_ $$2doi$$a10.1038/s41598-024-54051-7
000133116 0248_ $$2sideral$$a137852
000133116 037__ $$aART-2024-137852
000133116 041__ $$aeng
000133116 100__ $$0(orcid)0000-0002-3888-7036$$aRamirez-Labrada, Ariel
000133116 245__ $$aMultiparametric in vitro and in vivo analysis of the safety profile of self-assembling peptides
000133116 260__ $$c2024
000133116 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133116 5203_ $$aSelf-assembling peptides (SAPs) have gained significant attention in biomedicine because of their unique properties and ability to undergo molecular self-assembly driven by non-covalent interactions. By manipulating their composition and structure, SAPs can form well-ordered nanostructures with enhanced selectivity, stability and biocompatibility. SAPs offer advantages such as high chemical and biological diversity and the potential for functionalization. However, studies concerning its potentially toxic effects are very scarce, a limitation that compromises its potential translation to humans. This study investigates the potentially toxic effects of six different SAP formulations composed of natural amino acids designed for nervous tissue engineering and amenable to ready cross-linking boosting their biomechanical properties. All methods were performed in accordance with the relevant guidelines and regulations. A wound-healing assay was performed to evaluate how SAPs modify cell migration. The results in vitro demonstrated that SAPs did not induce genotoxicity neither skin sensitization. In vivo, SAPs were well-tolerated without any signs of acute systemic toxicity. Interestingly, SAPs were found to promote the migration of endothelial, macrophage, fibroblast, and neuronal-like cells in vitro, supporting a high potential for tissue regeneration. These findings contribute to the development and translation of SAP-based biomaterials for biomedical applications.
000133116 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-113963RB-I00$$9info:eu-repo/grantAgreement/ES/AEI/RYC2022-036627-I$$9info:eu-repo/grantAgreement/ES/DGA/B29-23R$$9info:eu-repo/grantAgreement/ES/DGA/LMP139-21$$9info:eu-repo/grantAgreement/ES/ISCIII/CB21-13-00087
000133116 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000133116 590__ $$a3.9$$b2024
000133116 592__ $$a0.874$$b2024
000133116 591__ $$aMULTIDISCIPLINARY SCIENCES$$b25 / 135 = 0.185$$c2024$$dQ1$$eT1
000133116 593__ $$aMultidisciplinary$$c2024$$dQ1
000133116 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133116 700__ $$aSantiago, Llipsy
000133116 700__ $$aPesini, Cecilia
000133116 700__ $$aArrieta, Marta
000133116 700__ $$0(orcid)0000-0002-9730-2210$$aArias, Maykel
000133116 700__ $$aCalvo Pérez, Adanays
000133116 700__ $$aCiulla, Maria Gessica
000133116 700__ $$aForouharshad, Mahdi
000133116 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, Julian$$uUniversidad de Zaragoza
000133116 700__ $$aGálvez, Eva M.
000133116 700__ $$aGelain, Fabrizio
000133116 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000133116 773__ $$g14, 1 (2024), 4395 [19 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000133116 8564_ $$s7274382$$uhttps://zaguan.unizar.es/record/133116/files/texto_completo.pdf$$yVersión publicada
000133116 8564_ $$s2111988$$uhttps://zaguan.unizar.es/record/133116/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133116 909CO $$ooai:zaguan.unizar.es:133116$$particulos$$pdriver
000133116 951__ $$a2025-09-22-14:31:09
000133116 980__ $$aARTICLE