Use of a local anaesthetic and antiseptic wound formulation for the treatment of lambs naturally infected with Orf virus

Gómez, Álex (Universidad de Zaragoza) ; Lacasta, Delia (Universidad de Zaragoza) ; Tejedor, María Teresa (Universidad de Zaragoza) ; Ruiz de Arcaute, Marta (Universidad de Zaragoza) ; Ramos, Juan José (Universidad de Zaragoza) ; Ruiz, Héctor (Universidad de Zaragoza) ; Ortín, Aurora (Universidad de Zaragoza) ; Villanueva-Saz, Sergio (Universidad de Zaragoza) ; Reina, Ramsés ; Quílez, Pablo (Universidad de Zaragoza) ; Navarro, Teresa (Universidad de Zaragoza) ; Verde, Maite (Universidad de Zaragoza) ; Borobia, Marta (Universidad de Zaragoza) ; Windsor, Peter Andrew

Resumen: Contagious ecthyma (CE) is a worldwide highly contagious zoonotic viral skin disease of sheep and goats. Treatment for Orf virus (ORFV) infection usually involves topical and oral antibiotics. An anaesthetic and antiseptic topical gel (Multisolfen® or Tri-Solfen®; MS®, Medical Ethics, Australia) has been documented as an efficacious therapy for lesions from mucosal and epithelial viral infections in ruminants. The present study tested a new treatment protocol of MS® for CE therapy on-farm in 150 lambs naturally infected with ORFV. Lambs were divided into three cohorts of 50 lambs each (C, D and E). Cohort C was treated with MS® 3 times with an interval of 3 days between treatments, cohort D was treated daily with hypochlorous acid, whilst cohort E served as untreated controls. The lambs were examined clinically every two days, weight measured weekly, with whole blood and sterile swabs from ORFV lesions collected for haematological analysis and specific ORFV PCR. Cohort C presented fewer lambs displaying ORFV-associated lesions than other cohorts at different times of the experiment. Further, lesions treated with MS® were milder compared with other cohorts. However, following cessation of therapy, most of the lambs again developed ORFV-associated lesions. No differences between cohorts were observed in weight, haematological and PCR results. These findings suggest that topical treatment with MS® is effective for CE in field conditions, especially in the first stages of the clinical course, although treatment with MS® may need to be extended a minimum of 4 weeks.

Idioma: Inglés

DOI: 10.1016/j.vetmic.2024.110037

Año: 2024

Publicado en: Veterinary Microbiology 292 (2024), 110037 [7 pp.]
ISSN: 0378-1135

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/Construyendo Aragón 2016–2020-A15-17R

Tipo y forma: Article (Published version)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)