Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
Miralles-Comins, Sara ; Zanatta, Marcileia ; García Embid, Sonia ; Alleva, María ; Chiappone, Annalisa ; Roppolo, Ignazio ; Mitchell, Scott G. ; Sans, Victor
Resumen: The bigger picture
In the quest to address global antibiotic resistance, this study pioneers 3D-printable antimicrobial polymeric scaffolds with embedded copper-based nanoparticles. A polymeric formulation based on polymeric ionic liquids has been carefully designed to overcome nanoparticle stabilization challenges, while being optimized for 3D printing. Customized formulations for digital light processing and masked stereolithography-based 3D printing are introduced, resulting in high-resolution materials with potent antimicrobial properties. Successful 3D printing of a device analogous to a medical stent demonstrated their efficacy against the growth of S. epidermidis bacteria. This research underscores additive manufacturing’s transformative potential for high-resolution devices, contributing significantly to a critical global health concern. It establishes a foundation for diverse antimicrobial solutions, marking a substantial advancement in the field.
Summary
In recent years, 3D printing has undergone a significant transformation, expanding beyond its initial niche applications, such as rapid prototyping and hobbyist projects. This evolution has been characterized by advancements in equipment, software, and, most notably, materials. However, the development of materials that present high-resolution and advanced tunable functionalities is still a challenge. Herein, we report the development of modular 3D-printable antimicrobial polymeric ionic liquid (PIL) scaffolds with in situ formation of copper-based nanoparticles within the polymeric matrix (Cu@PILs). A variety of formulations were specially designed and optimized to be printed by digital light processing and masked stereolithography techniques at high resolution. The antimicrobial activity as well as the biocompatibility of the different formulations was tested, changing the monomeric ionic liquid and the photoinitiator. Tailor-made objects were successfully manufactured, and as a demonstrator, a geometry compatible with a medical stent was printed.
Idioma: Inglés
DOI: 10.1016/j.device.2023.100224
Año: 2024
Publicado en: Device 2, 2 (2024), 100224 [12 pp.]
ISSN: 2666-9986
Financiación: info:eu-repo/grantAgreement/EC/H2020/101026335/EU/Efficient CO2 capture and valorisation with 3D printed catalytic reactors/3DPILcat
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2022-141276OB-I00
Tipo y forma: Artículo (Versión definitiva)
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Exportado de SIDERAL (2024-04-12-13:59:47)
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In the quest to address global antibiotic resistance, this study pioneers 3D-printable antimicrobial polymeric scaffolds with embedded copper-based nanoparticles. A polymeric formulation based on polymeric ionic liquids has been carefully designed to overcome nanoparticle stabilization challenges, while being optimized for 3D printing. Customized formulations for digital light processing and masked stereolithography-based 3D printing are introduced, resulting in high-resolution materials with potent antimicrobial properties. Successful 3D printing of a device analogous to a medical stent demonstrated their efficacy against the growth of S. epidermidis bacteria. This research underscores additive manufacturing’s transformative potential for high-resolution devices, contributing significantly to a critical global health concern. It establishes a foundation for diverse antimicrobial solutions, marking a substantial advancement in the field.
Summary
In recent years, 3D printing has undergone a significant transformation, expanding beyond its initial niche applications, such as rapid prototyping and hobbyist projects. This evolution has been characterized by advancements in equipment, software, and, most notably, materials. However, the development of materials that present high-resolution and advanced tunable functionalities is still a challenge. Herein, we report the development of modular 3D-printable antimicrobial polymeric ionic liquid (PIL) scaffolds with in situ formation of copper-based nanoparticles within the polymeric matrix (Cu@PILs). A variety of formulations were specially designed and optimized to be printed by digital light processing and masked stereolithography techniques at high resolution. The antimicrobial activity as well as the biocompatibility of the different formulations was tested, changing the monomeric ionic liquid and the photoinitiator. Tailor-made objects were successfully manufactured, and as a demonstrator, a geometry compatible with a medical stent was printed.
Idioma: Inglés
DOI: 10.1016/j.device.2023.100224
Año: 2024
Publicado en: Device 2, 2 (2024), 100224 [12 pp.]
ISSN: 2666-9986
Financiación: info:eu-repo/grantAgreement/EC/H2020/101026335/EU/Efficient CO2 capture and valorisation with 3D printed catalytic reactors/3DPILcat
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2022-141276OB-I00
Tipo y forma: Artículo (Versión definitiva)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. Exportado de SIDERAL (2024-04-12-13:59:47)
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Registro creado el 2024-04-12, última modificación el 2024-04-12