Synthesis and immunological evaluation of TLR1/2 ligand-conjugated RBDs as self-adjuvanting vaccine candidates against SARS-CoV-2

Manabe, Yoshiyuki ; Gárate-Reyes, Brandon ; Ito, Keita ; Hurtado-Guerrero, Ramón ; Kabayama, Kazuya ; Fukase, Koichi

Resumen: We synthesized and evaluated Pam3CSK4-conjugated receptor binding domain (RBD)/deglycosylated RBD as potential anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates. Our investigation revealed the critical importance of limiting the number of introduced Pam3CSK4 molecules to the RBD in order to preserve its antigenicity. We also confirmed the harmonious integration of the adjuvant-conjugation strategy with the glycan-shield removal strategy.

Idioma: Inglés

DOI: 10.1039/d4cc00462k

Año: 2024

Publicado en: Chemical Communications 60, 29 (2024), 4 pp.
ISSN: 1359-7345

Factor impacto JCR: 4.2 (2024)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 84 / 239 = 0.351 (2024) - Q2 - T2

Factor impacto CITESCORE: 7.4 - Electronic, Optical and Magnetic Materials (Q1) - Chemistry (all) (Q1) - Materials Chemistry (Q1) - Surfaces, Coatings and Films (Q1) - Ceramics and Composites (Q2) - Metals and Alloys (Q1) - Catalysis (Q2)

Factor impacto SCIMAGO: 1.037 - Electronic, Optical and Magnetic Materials (Q1) - Ceramics and Composites (Q1) - Chemistry (miscellaneous) (Q1) - Surfaces, Coatings and Films (Q1) - Materials Chemistry (Q1) - Metals and Alloys (Q1) - Catalysis (Q2)

Financiación: info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-136362NB-I00

Tipo y forma: Congress (Published version)