Synthesis and immunological evaluation of TLR1/2 ligand-conjugated RBDs as self-adjuvanting vaccine candidates against SARS-CoV-2
Manabe, Yoshiyuki ; Gárate-Reyes, Brandon ; Ito, Keita ; Hurtado-Guerrero, Ramón ; Kabayama, Kazuya ; Fukase, Koichi
Resumen: We synthesized and evaluated Pam3CSK4-conjugated receptor binding domain (RBD)/deglycosylated RBD as potential anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates. Our investigation revealed the critical importance of limiting the number of introduced Pam3CSK4 molecules to the RBD in order to preserve its antigenicity. We also confirmed the harmonious integration of the adjuvant-conjugation strategy with the glycan-shield removal strategy.
Idioma: Inglés
DOI: 10.1039/d4cc00462k
Año: 2024
Publicado en: Chemical Communications 60, 29 (2024), 4 pp.
ISSN: 1359-7345
Financiación: info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-136362NB-I00
Tipo y forma: Congress (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2024-04-24-13:24:05)
Visitas y descargas
Idioma: Inglés
DOI: 10.1039/d4cc00462k
Año: 2024
Publicado en: Chemical Communications 60, 29 (2024), 4 pp.
ISSN: 1359-7345
Financiación: info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-136362NB-I00
Tipo y forma: Congress (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2024-04-24-13:24:05)
Permalink:
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
Articles
Record created 2024-04-24, last modified 2024-04-24