000134593 001__ 134593
000134593 005__ 20240731103351.0
000134593 0247_ $$2doi$$a10.1039/d4nh00064a
000134593 0248_ $$2sideral$$a138214
000134593 037__ $$aART-2024-138214
000134593 041__ $$aeng
000134593 100__ $$0(orcid)0000-0003-4970-2460$$aLacueva-Aparicio, Alodia
000134593 245__ $$aA microphysiological system for handling graphene related materials under flow conditions
000134593 260__ $$c2024
000134593 5060_ $$aAccess copy available to the general public$$fUnrestricted
000134593 5203_ $$aThe field of nanotechnology has developed rapidly in recent decades due to its broad applications in many industrial and biomedical fields. Notably, 2D materials such as graphene-related materials (GRMs) have been extensively explored and, as such, their safety needs to be assessed. However, GRMs tend to deposit quickly, present low stability in aqueous solutions, and adsorb to plastic materials. Consequently, traditional approaches based on static assays facilitate their deposition and adsorption and fail to recreate human physiological conditions. Organ-on-a-chip (OOC) technology could, however, solve these drawbacks and lead to the development of microphysiological systems (MPSs) that mimic the microenvironment present in human tissues. In light of the above, in the present study a microfluidic system under flow conditions has been optimised to minimise graphene oxide (GO) and few-layer graphene (FLG) adsorption and deposition. For that purpose, a kidney-on-a-chip was developed and optimised to evaluate the effects of exposure to GO and FLG flakes at a sublethal dose under fluid flow conditions. In summary, MPSs are an innovative and precise tool for evaluating the effects of exposure to GRMs and other type of nanomaterials.
000134593 536__ $$9info:eu-repo/grantAgreement/EC/H2020/881603/EU/Graphene Flagship Core Project 3/GrapheneCore3$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 881603-GrapheneCore3$$9info:eu-repo/grantAgreement/ES/MICINN/AEI/PID2020-113080RB-I00
000134593 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000134593 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000134593 700__ $$aGonzález, Viviana Jehová
000134593 700__ $$0(orcid)0000-0002-1075-8267$$aRemacha, Ana Rosa
000134593 700__ $$aWoods, Daniel
000134593 700__ $$aPrado, Eduardo
000134593 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, Ignacio$$uUniversidad de Zaragoza
000134593 700__ $$0(orcid)0000-0003-0156-4230$$aOliván, Sara$$uUniversidad de Zaragoza
000134593 700__ $$aVázquez, Ester
000134593 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000134593 773__ $$g9, 6 (2024), 990-1001$$pNanoscale Horizons$$tNanoscale Horizons$$x2055-6756
000134593 8564_ $$s2563522$$uhttps://zaguan.unizar.es/record/134593/files/texto_completo.pdf$$yVersión publicada
000134593 8564_ $$s2846323$$uhttps://zaguan.unizar.es/record/134593/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000134593 909CO $$ooai:zaguan.unizar.es:134593$$particulos$$pdriver
000134593 951__ $$a2024-07-31-09:54:33
000134593 980__ $$aARTICLE