Capi-score: a quantitative algorithm for identifying disease patterns in nailfold videocapillaroscopy
Gracia Tello, Borja del Carmelo (Universidad de Zaragoza) ; Sáez Comet, Luis (Universidad de Zaragoza) ; Lledó, Gema ; Freire Dapena, Mayka ; Mesa, Miguel Antonio ; Martín-Cascón, Miguel ; Guillén del Castillo, Alfredo ; Martínez Robles, Elena ; Simeón-Aznar, Carmen Pilar ; Todolí Parra, Jose Antonio ; Varela, Diana Cristina ; Maldonado Vélez, Genessis ; Marín Ballvé, Adela (Universidad de Zaragoza) ; Aramburu Llorente, Jimena ; Pérez Abad, Laura ; Ramos Ibáñez, Eduardo
Resumen: Objectives
EULAR supports the use of nailfold videocapillaroscopy (NVC) for identifying disease patterns (DPs) associated with SSc and RP. Recently, EULAR proposed an easy-to-manage procedure, a so-called Fast Track algorithm, for differentiating SSc patterns from non-SSc patterns in NVC specimens. However, subjectivity among capillaroscopists remains a limitation. Our aim was to perform a software-based analysis of NVC peculiarities in a cohort of samples from SSc and RP patients and, subsequently, build a Fast Track–inspired algorithm for identifying DPs without the constraint of interobserver variability.
Methods
NVCs were examined by 9 capillaroscopists. Those NVCs whose DPs were consensually agreed upon (by ≥2 out of 3 interobservers) were subsequently analysed using in-house–developed software. The results for each variable were grouped according to the consensually agreed-upon DPs in order to identify useful hallmarks for categorizing them.
Results
A total of 851 NVCs (21 957 images) whose DPs had been consensually agreed upon were software-analysed. Appropriate cut-offs set for capillary density and percentage of abnormal and giant capillaries, tortuosities and haemorrhages allowed DP categorization and the development of the CAPI-score algorithm. This consisted of four rules: Rule 1, SSc vs non-SSc, accuracy 0.88; Rules 2 and 3, SSc-early vs SSc-active vs SSc-late, accuracy 0.82; Rule 4, non-SSc normal vs non-SSc non-specific, accuracy 0.73. Accuracy improved when the analysis was limited to NVCs whose DPs had achieved full consensus between the interobservers.
Conclusion
The CAPI-score algorithm may become a tool that is useful in assigning DPs by overcoming the limitations of subjectivity.
Idioma: Inglés
DOI: 10.1093/rheumatology/keae197
Año: 2024
Publicado en: Rheumatology (Oxford) 63, 12 (2024), 3315–3321
ISSN: 1462-0324
Factor impacto JCR: 4.4 (2024)
Categ. JCR: RHEUMATOLOGY rank: 9 / 58 = 0.155 (2024) - Q1 - T1
Factor impacto SCIMAGO: 1.721 - Rheumatology (Q1) - Pharmacology (medical) (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2025-09-22-14:39:54)
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EULAR supports the use of nailfold videocapillaroscopy (NVC) for identifying disease patterns (DPs) associated with SSc and RP. Recently, EULAR proposed an easy-to-manage procedure, a so-called Fast Track algorithm, for differentiating SSc patterns from non-SSc patterns in NVC specimens. However, subjectivity among capillaroscopists remains a limitation. Our aim was to perform a software-based analysis of NVC peculiarities in a cohort of samples from SSc and RP patients and, subsequently, build a Fast Track–inspired algorithm for identifying DPs without the constraint of interobserver variability.
Methods
NVCs were examined by 9 capillaroscopists. Those NVCs whose DPs were consensually agreed upon (by ≥2 out of 3 interobservers) were subsequently analysed using in-house–developed software. The results for each variable were grouped according to the consensually agreed-upon DPs in order to identify useful hallmarks for categorizing them.
Results
A total of 851 NVCs (21 957 images) whose DPs had been consensually agreed upon were software-analysed. Appropriate cut-offs set for capillary density and percentage of abnormal and giant capillaries, tortuosities and haemorrhages allowed DP categorization and the development of the CAPI-score algorithm. This consisted of four rules: Rule 1, SSc vs non-SSc, accuracy 0.88; Rules 2 and 3, SSc-early vs SSc-active vs SSc-late, accuracy 0.82; Rule 4, non-SSc normal vs non-SSc non-specific, accuracy 0.73. Accuracy improved when the analysis was limited to NVCs whose DPs had achieved full consensus between the interobservers.
Conclusion
The CAPI-score algorithm may become a tool that is useful in assigning DPs by overcoming the limitations of subjectivity.
Idioma: Inglés
DOI: 10.1093/rheumatology/keae197
Año: 2024
Publicado en: Rheumatology (Oxford) 63, 12 (2024), 3315–3321
ISSN: 1462-0324
Factor impacto JCR: 4.4 (2024)
Categ. JCR: RHEUMATOLOGY rank: 9 / 58 = 0.155 (2024) - Q1 - T1
Factor impacto SCIMAGO: 1.721 - Rheumatology (Q1) - Pharmacology (medical) (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2025-09-22-14:39:54)
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Record created 2024-06-05, last modified 2025-09-23