Characterization of camphor: thymol or dl-menthol eutectic mixtures; Structure, thermophysical properties, and lidocaine solubility
Padilla, Nuria ; Delso, Ignacio ; Bergua, Fernando (Universidad de Zaragoza) ; Lafuente, Carlos (Universidad de Zaragoza) ; Artal, Manuela (Universidad de Zaragoza)
Resumen: The low solubility of drugs in aqueous media is a major problem for the pharmaceutical industry. Among the solutions proposed, the use of eutectic mixtures can be highlighted. In them, the components used can also increase the therapeutic advantages of the active principle. In this work, we analyzed the solubility of lidocaine in mixtures of camphor + thymol or dl-menthol. These binary eutectic solvents were also characterized. For all this, several NMR techniques were used and different thermophysical properties (density, speed of sound, refraction index, isobaric molar heat capacity, surface tension, and kinematic viscosity) were measured. The results indicated that the interaction of camphor with thymol was stronger than with dl-menthol, providing a more compact fluid. On the contrary, the steric hindrance was greater in the mixture with dl-menthol, giving rise to a more viscous liquid. Furthermore, the lidocaine was significantly more soluble (up to 540 times) in these mixtures than in water. The lidocaine showed the strongest interactions with thymol molecules, somewhat weaker with dl-menthol, and the weakest were with camphor ones.
Idioma: Inglés
DOI: 10.1016/j.molliq.2024.125069
Año: 2024
Publicado en: Journal of Molecular Liquids 405 (2024), 125069 [13 pp.]
ISSN: 0167-7322
Financiación: info:eu-repo/grantAgreement/ES/DGA/E31-23R
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Física (Dpto. Química Física)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.1016/j.molliq.2024.125069
Año: 2024
Publicado en: Journal of Molecular Liquids 405 (2024), 125069 [13 pp.]
ISSN: 0167-7322
Financiación: info:eu-repo/grantAgreement/ES/DGA/E31-23R
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Física (Dpto. Química Física)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-06-14-09:00:07)
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Record created 2024-06-14, last modified 2024-06-14