Zárate Roldán, Silvia Stephany
Gimeno Floría, María Concepción (dir.) ; Pérez Herrera, Raquel (dir.)
Universidad de Zaragoza,
2024
Abstract: The thesis focuses on various methodologies in organic chemistry, specifically homogeneous catalysis, explored across multiple chapters. One chapter investigates using gold catalysis to synthesize propargylamines and oxidize aldehydes without direct manipulation. It likely includes an analysis of reaction pathways and mechanism insights. Additionally, it discusses biological applications using different propargylamines coordinated with gold complexes, calculating IC50.
Another chapter extends the scope to encompass the alkylation of nucleophilic derivatives using various substrates, such as alcohols, amides, hydrazides, etc. The chapter analyzes reaction conditions and substrate compatibility and delves into Friedel-Crafts alkylation of indoles within deep eutectic solvents. It examines the advantages of deep eutectic solvents over traditional solvents and likely includes discussions on reaction mechanisms and conditions influencing selectivity.
The final chapter concentrates on chiral DES for aldol reactions, utilizing L-proline and glycols as catalysts to achieve high enantioselectivity and diastereomeric ratio. This section delves into synthetic applications and potential mechanistic pathways. Throughout the thesis, detailed experimental procedures, characterization data, and mechanistic insights are provided, supported by pertinent literature. The integration of graphical representations enhances the clarity and comprehension of the research findings.
Abstract (other lang.):
Another chapter extends the scope to encompass the alkylation of nucleophilic derivatives using various substrates, such as alcohols, amides, hydrazides, etc. The chapter analyzes reaction conditions and substrate compatibility and delves into Friedel-Crafts alkylation of indoles within deep eutectic solvents. It examines the advantages of deep eutectic solvents over traditional solvents and likely includes discussions on reaction mechanisms and conditions influencing selectivity.
The final chapter concentrates on chiral DES for aldol reactions, utilizing L-proline and glycols as catalysts to achieve high enantioselectivity and diastereomeric ratio. This section delves into synthetic applications and potential mechanistic pathways. Throughout the thesis, detailed experimental procedures, characterization data, and mechanistic insights are provided, supported by pertinent literature. The integration of graphical representations enhances the clarity and comprehension of the research findings.
Abstract (other lang.):
Pal. clave: química orgánica ; catálisis
Titulación: Programa de Doctorado en Química Orgánica
Plan(es): Plan 494
Knowledge area: Ciencias
Nota: Presentado: 21 03 2024
Nota: Tesis-Univ. Zaragoza, , 2024
Contribution of the TFG/M to Sustainability: Garantizar una educación de calidad inclusiva y equitativa, y promover las oportunidades de aprendizaje permanente para todos. Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación. Garantizar las pautas de consumo y de producción sostenibles.
Fecha de embargo : 2026-03-21
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Record created 2024-06-21, last modified 2024-06-21
