000135985 001__ 135985
000135985 005__ 20240704095849.0
000135985 0247_ $$2doi$$a10.1016/j.jtice.2024.105631
000135985 0248_ $$2sideral$$a139012
000135985 037__ $$aART-2024-139012
000135985 041__ $$aeng
000135985 100__ $$aMolero Sangüesa, María
000135985 245__ $$aThermophysical properties of lidocaine:thymol or l-menthol eutectic mixtures
000135985 260__ $$c2024
000135985 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135985 5203_ $$aBackgrounds
A key objective of green chemistry is to obtain a broad database of thermophysical properties of liquid mixtures. Thus, the replacement of conventional solvents with ecological ones will be facilitated.
Methods
Herein, two eutectic systems with therapeutic properties are characterized. They are binary mixtures of lidocaine and thymol or l-menthol. Properties as solid-liquid equilibrium, density, speed of sound, refractive index, isobaric molar heat capacity, surface tension, and viscosity were determined at 0.1 MPa and several temperatures. From them, others derivatives were calculated. In addition, the phase diagram was correlated with NRTL model and the density and isobaric molar heat capacity were modelled with PC-SAFT equation of state.
Significant findings
Although the mixtures with l-menthol were almost ideal, a complex diagram owing the presence of stable and metastable phases. For these mixtures, the values of all measured properties were lower than those with thymol. Results indicated that PC-SAFT can be used to predict the thermodynamic behaviour of both systems in any working condition.
000135985 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E31-23R
000135985 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000135985 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135985 700__ $$aJiménez Omeñaca, Isabel
000135985 700__ $$0(orcid)0000-0003-3641-1568$$aBergua, Fernando$$uUniversidad de Zaragoza
000135985 700__ $$0(orcid)0000-0001-8790-8211$$aArtigas, Héctor$$uUniversidad de Zaragoza
000135985 700__ $$0(orcid)0000-0003-3632-6822$$aLafuente, Carlos$$uUniversidad de Zaragoza
000135985 700__ $$0(orcid)0000-0003-1810-9488$$aArtal, Manuela$$uUniversidad de Zaragoza
000135985 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000135985 773__ $$g163 (2024), 105631 [9 pp.]$$pJournal of the Taiwan Institute of Chemical Engineers$$tJournal of the Taiwan Institute of Chemical Engineers$$x1876-1070
000135985 8564_ $$s1587918$$uhttps://zaguan.unizar.es/record/135985/files/texto_completo.pdf$$yVersión publicada
000135985 8564_ $$s2622324$$uhttps://zaguan.unizar.es/record/135985/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135985 909CO $$ooai:zaguan.unizar.es:135985$$particulos$$pdriver
000135985 951__ $$a2024-07-04-07:59:35
000135985 980__ $$aARTICLE