000136097 001__ 136097
000136097 005__ 20260112133320.0
000136097 0247_ $$2doi$$a10.1038/s41586-024-07546-2
000136097 0248_ $$2sideral$$a139060
000136097 037__ $$aART-2024-139060
000136097 041__ $$aeng
000136097 100__ $$aMichel, Megan
000136097 245__ $$aAncient Plasmodium genomes shed light on the history of human malaria
000136097 260__ $$c2024
000136097 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136097 5203_ $$aMalaria-causing protozoa of the genus Plasmodium have exerted one of the strongest selective pressures on the human genome, and resistance alleles provide biomolecular footprints that outline the historical reach of these species1. Nevertheless, debate persists over when and how malaria parasites emerged as human pathogens and spread around the globe1,2. To address these questions, we generated high-coverage ancient mitochondrial and nuclear genome-wide data from P. falciparum, P. vivax and P. malariae from 16 countries spanning around 5,500 years of human history. We identified P. vivax and P. falciparum across geographically disparate regions of Eurasia from as early as the fourth and first millennia bce, respectively; for P. vivax, this evidence pre-dates textual references by several millennia3. Genomic analysis supports distinct disease histories for P. falciparum and P. vivax in the Americas: similarities between now-eliminated European and peri-contact South American strains indicate that European colonizers were the source of American P. vivax, whereas the trans-Atlantic slave trade probably introduced P. falciparum into the Americas. Our data underscore the role of cross-cultural contacts in the dissemination of malaria, laying the biomolecular foundation for future palaeo-epidemiological research into the impact of Plasmodium parasites on human history. Finally, our unexpected discovery of P. falciparum in the high-altitude Himalayas provides a rare case study in which individual mobility can be inferred from infection status, adding to our knowledge of cross-cultural connectivity in the region nearly three millennia ago.
000136097 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000136097 590__ $$a48.5$$b2024
000136097 592__ $$a18.288$$b2024
000136097 591__ $$aMULTIDISCIPLINARY SCIENCES$$b2 / 135 = 0.015$$c2024$$dQ1$$eT1
000136097 593__ $$aMultidisciplinary$$c2024$$dQ1
000136097 594__ $$a78.1$$b2024
000136097 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136097 700__ $$aSkourtanioti, Eirini
000136097 700__ $$aPierini, Federica
000136097 700__ $$aGuevara, Evelyn K.
000136097 700__ $$aMötsch, Angela
000136097 700__ $$aKocher, Arthur
000136097 700__ $$aBarquera, Rodrigo
000136097 700__ $$aBianco, Raffaela A.
000136097 700__ $$aCarlhoff, Selina
000136097 700__ $$aCoppola Bove, Lorenza
000136097 700__ $$aFreilich, Suzanne
000136097 700__ $$aGiffin, Karen
000136097 700__ $$aHermes, Taylor
000136097 700__ $$aHiß, Alina
000136097 700__ $$aKnolle, Florian
000136097 700__ $$aNelson, Elizabeth A.
000136097 700__ $$aNeumann, Gunnar U.
000136097 700__ $$aPapac, Luka
000136097 700__ $$aPenske, Sandra
000136097 700__ $$aRohrlach, Adam B.
000136097 700__ $$aSalem, Nada
000136097 700__ $$aSemerau, Lena
000136097 700__ $$0(orcid)0000-0002-9357-5238$$aVillalba-Mouco, Vanessa
000136097 700__ $$aAbadie, Isabelle
000136097 700__ $$aAldenderfer, Mark
000136097 700__ $$aBeckett, Jessica F.
000136097 700__ $$aBrown, Matthew
000136097 700__ $$aCampus, Franco G. R.
000136097 700__ $$aChenghwa, Tsang
000136097 700__ $$aCruz Berrocal, María
000136097 700__ $$aDamašek, Ladislav
000136097 700__ $$aDuffett Carlson, Kellie Sara
000136097 700__ $$aDurand, Raphaël
000136097 700__ $$aErnée, Michal
000136097 700__ $$aFântaneanu, Cristinel
000136097 700__ $$aFrenzel, Hannah
000136097 700__ $$aGarcía Atiénzar, Gabriel
000136097 700__ $$aGuillén, Sonia
000136097 700__ $$aHsieh, Ellen
000136097 700__ $$aKarwowski, Maciej
000136097 700__ $$aKelvin, David
000136097 700__ $$aKelvin, Nikki
000136097 700__ $$aKhokhlov, Alexander
000136097 700__ $$aKinaston, Rebecca L.
000136097 700__ $$aKorolev, Arkadii
000136097 700__ $$aKrettek, Kim-Louise
000136097 700__ $$aKüßner, Mario
000136097 700__ $$aLai, Luca
000136097 700__ $$aLook, Cory
000136097 700__ $$aMajander, Kerttu
000136097 700__ $$aMandl, Kirsten
000136097 700__ $$aMazzarello, Vittorio
000136097 700__ $$aMcCormick, Michael
000136097 700__ $$ade Miguel Ibáñez, Patxuka
000136097 700__ $$aMurphy, Reg
000136097 700__ $$aNémeth, Rita E.
000136097 700__ $$aNordqvist, Kerkko
000136097 700__ $$aNovotny, Friederike
000136097 700__ $$aObenaus, Martin
000136097 700__ $$aOlmo-Enciso, Lauro
000136097 700__ $$aOnkamo, Päivi
000136097 700__ $$aOrschiedt, Jörg
000136097 700__ $$aPatrushev, Valerii
000136097 700__ $$aPeltola, Sanni
000136097 700__ $$aRomero, Alejandro
000136097 700__ $$aRubino, Salvatore
000136097 700__ $$aSajantila, Antti
000136097 700__ $$aSalazar-García, Domingo C.
000136097 700__ $$aSerrano, Elena
000136097 700__ $$aShaydullaev, Shapulat
000136097 700__ $$aSias, Emanuela
000136097 700__ $$aŠlaus, Mario
000136097 700__ $$aStanco, Ladislav
000136097 700__ $$aSwanston, Treena
000136097 700__ $$aTeschler-Nicola, Maria
000136097 700__ $$aValentin, Frederique
000136097 700__ $$aVan de Vijver, Katrien
000136097 700__ $$aVarney, Tamara L.
000136097 700__ $$aVigil-Escalera Guirado, Alfonso
000136097 700__ $$aWaters, Christopher K.
000136097 700__ $$aWeiss-Krejci, Estella
000136097 700__ $$aWinter, Eduard
000136097 700__ $$aLamnidis, Thiseas C.
000136097 700__ $$aPrüfer, Kay
000136097 700__ $$aNägele, Kathrin
000136097 700__ $$aSpyrou, Maria
000136097 700__ $$aSchiffels, Stephan
000136097 700__ $$aStockhammer, Philipp W.
000136097 700__ $$aHaak, Wolfgang
000136097 700__ $$aPosth, Cosimo
000136097 700__ $$aWarinner, Christina
000136097 700__ $$aBos, Kirsten I.
000136097 700__ $$aHerbig, Alexander
000136097 700__ $$aKrause, Johannes
000136097 773__ $$g631 (2024), 125-133$$pNature$$tNature$$x0028-0836
000136097 8564_ $$s2135952$$uhttps://zaguan.unizar.es/record/136097/files/texto_completo.pdf$$yVersión publicada
000136097 8564_ $$s3399681$$uhttps://zaguan.unizar.es/record/136097/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000136097 951__ $$a2026-01-12-13:06:31
000136097 980__ $$aARTICLE