Remote magneto–thermal modulation of reactive oxygen species balance enhances tissue regeneration in vivo
Tommasini, Giuseppina ; Sol-Fernández, Susel Del ; Flavián-Lázaro, Ana Cristina ; Lewinska, Anna ; Wnuk, Maciej ; Tortiglione, Claudia ; Moros, María
Resumen: One of the hallmarks of tissue repair is the production of reactive oxygen species (ROS), which modulate processes such as cell proliferation. Although several attempts have been made to manipulate ROS levels to increase tissue repair, the lack of techniques able to remotely manipulate the redox homeostasis with spatio–temporal fashion has hindered its progress. Herein, a new approach for tuning the ROS levels using magnetic nanoparticles (MNPs) that act as nanoheaters when exposed to an alternating magnetic field is presented. Two manganese–iron oxide (MnxFe3−xO4) MNPs (with a low and a high Mn2+ content) are designed and probed for the possibility of modulating the ROS balance by magneto–thermal stimulation in the invertebrate model organism Hydra vulgaris, able to fully regenerate. By evaluating the expression of selected genes involved in the maintenance of ROS homeostasis and proliferation pathways, a biphasic modulation of the ROS levels played by the MNPs is found. While MNPs with a lower Mn2+ content are able to positively modulate the regeneration potential under magnetostimulation, MNPs with a higher Mn2+ content cause a different redox imbalance, negatively affecting the regeneration dynamic. This innovative approach reveals a novel way of manipulating redox homeostasis that can advance in the field of tissue engineering.
Idioma: Inglés
DOI: 10.1002/adfm.202405282
Año: 2024
Publicado en: Advanced Functional Materials 34, 39 (2024), 2405282 [16 pp.]
ISSN: 1616-301X
Factor impacto JCR: 19.0 (2024)
Categ. JCR: CHEMISTRY, PHYSICAL rank: 12 / 185 = 0.065 (2024) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 23 / 460 = 0.05 (2024) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 9 / 147 = 0.061 (2024) - Q1 - T1
Categ. JCR: PHYSICS, CONDENSED MATTER rank: 5 / 79 = 0.063 (2024) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 13 / 239 = 0.054 (2024) - Q1 - T1
Categ. JCR: PHYSICS, APPLIED rank: 9 / 187 = 0.048 (2024) - Q1 - T1
Factor impacto CITESCORE: 27.7 - Materials Science (all) (Q1) - Condensed Matter Physics (Q1) - Chemistry (all) (Q1)
Factor impacto SCIMAGO: 5.439 - Biomaterials (Q1) - Chemistry (miscellaneous) (Q1) - Condensed Matter Physics (Q1) - Nanoscience and Nanotechnology (Q1) - Electronic, Optical and Magnetic Materials (Q1) - Materials Science (miscellaneous) (Q1) - Electrochemistry (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/E15-23R
Financiación: info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101064735/EU/Tunning the force for remote magnetomechanical gating of Piezo1 channels/MAGPIEZ
Financiación: info:eu-repo/grantAgreement/EC/H2020/853468/EU/Remote control of cellular signalling triggered by magnetic switching/SIROCCO
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CNS2022-135700
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2026-01-12-12:36:06)
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Idioma: Inglés
DOI: 10.1002/adfm.202405282
Año: 2024
Publicado en: Advanced Functional Materials 34, 39 (2024), 2405282 [16 pp.]
ISSN: 1616-301X
Factor impacto JCR: 19.0 (2024)
Categ. JCR: CHEMISTRY, PHYSICAL rank: 12 / 185 = 0.065 (2024) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 23 / 460 = 0.05 (2024) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 9 / 147 = 0.061 (2024) - Q1 - T1
Categ. JCR: PHYSICS, CONDENSED MATTER rank: 5 / 79 = 0.063 (2024) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 13 / 239 = 0.054 (2024) - Q1 - T1
Categ. JCR: PHYSICS, APPLIED rank: 9 / 187 = 0.048 (2024) - Q1 - T1
Factor impacto CITESCORE: 27.7 - Materials Science (all) (Q1) - Condensed Matter Physics (Q1) - Chemistry (all) (Q1)
Factor impacto SCIMAGO: 5.439 - Biomaterials (Q1) - Chemistry (miscellaneous) (Q1) - Condensed Matter Physics (Q1) - Nanoscience and Nanotechnology (Q1) - Electronic, Optical and Magnetic Materials (Q1) - Materials Science (miscellaneous) (Q1) - Electrochemistry (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/E15-23R
Financiación: info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101064735/EU/Tunning the force for remote magnetomechanical gating of Piezo1 channels/MAGPIEZ
Financiación: info:eu-repo/grantAgreement/EC/H2020/853468/EU/Remote control of cellular signalling triggered by magnetic switching/SIROCCO
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CNS2022-135700
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2026-01-12-12:36:06)
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Record created 2024-07-31, last modified 2026-01-12