| Página principal > Artículos > Microbiota-derived short-chain fatty acids boost antitumoral natural killer cell activity > MARC |
000136280 001__ 136280 000136280 005__ 20250923084425.0 000136280 0247_ $$2doi$$a10.3390/jcm13133885 000136280 0248_ $$2sideral$$a139263 000136280 037__ $$aART-2024-139263 000136280 041__ $$aeng 000136280 100__ $$aPérez, Marina 000136280 245__ $$aMicrobiota-derived short-chain fatty acids boost antitumoral natural killer cell activity 000136280 260__ $$c2024 000136280 5060_ $$aAccess copy available to the general public$$fUnrestricted 000136280 5203_ $$aBackground: The intestinal microbiota can regulate numerous host functions, including the immune response. Through fermentation, the microbiota produces and releases microbial metabolites such as short-chain fatty acids (SCFAs), which can affect host homeostasis. There is growing evidence that the gut microbiome can have a major impact on cancer. Specific gut microbial composition and metabolites are associated with tumor status in the host. However, their effects on the antitumor response have scarcely been investigated. Natural killer (NK) cells play an important role in antitumor immunity due to their ability to directly identify and eliminate tumor cells. Methods: The aim of this study was to investigate the effects of SCFAs on antitumoral NK cell activity, using NK-92 cell line. Results: Here, we describe how SCFAs can boost antitumoral NK cell activity. The SCFAs induced the release of NK extracellular vesicles and reduced the secretion of the anti-inflammatory cytokine IL-10. The SCFAs also increased the cytotoxicity of the NK cells against multiple myeloma cells. Conclusions: Our results indicate, for the first time, the enormous potential of SCFAs in regulating antitumoral NK cell defense, where modulation of the SCFAs’ production could play a fundamental role in cancer immunotherapy. 000136280 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B23-20R$$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2021-BIO-02 000136280 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000136280 590__ $$a2.9$$b2024 000136280 592__ $$a0.919$$b2024 000136280 591__ $$aMEDICINE, GENERAL & INTERNAL$$b65 / 332 = 0.196$$c2024$$dQ1$$eT1 000136280 593__ $$aMedicine (miscellaneous)$$c2024$$dQ1 000136280 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000136280 700__ $$0(orcid)0000-0002-8467-0356$$aBuey, Berta$$uUniversidad de Zaragoza 000136280 700__ $$aCorral, Pilar$$uUniversidad de Zaragoza 000136280 700__ $$aGiraldos, David 000136280 700__ $$0(orcid)0000-0002-5797-3909$$aLatorre, Eva$$uUniversidad de Zaragoza 000136280 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com 000136280 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular 000136280 773__ $$g13, 13 (2024), 3885 [12 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383 000136280 8564_ $$s1157572$$uhttps://zaguan.unizar.es/record/136280/files/texto_completo.pdf$$yVersión publicada 000136280 8564_ $$s2614089$$uhttps://zaguan.unizar.es/record/136280/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000136280 909CO $$ooai:zaguan.unizar.es:136280$$particulos$$pdriver 000136280 951__ $$a2025-09-22-14:38:50 000136280 980__ $$aARTICLE
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