000136372 001__ 136372
000136372 005__ 20240731105613.0
000136372 0247_ $$2doi$$a10.15761/HMO.1000173
000136372 0248_ $$2sideral$$a139298
000136372 037__ $$aART-2019-139298
000136372 041__ $$aeng
000136372 100__ $$aSantos-Lozano, Alejandro
000136372 245__ $$aGenetic factors and Waldenström's macroglobulinemia: Systematic review and meta-analysis
000136372 260__ $$c2019
000136372 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136372 5203_ $$aWaldenström's macroglobulinemia (WM) is categorized as a B-cell neoplasia characterized by lymphoplasmacytic infiltration in the bone marrow and the overproduction of serum monoclonal IgM. The precise cause of WM is unknown, but familial patterns suggest the possibility of an underlying genetic defect. The purpose of this study was to determine the association between different gene variations and the development of WM. We studied different genetic variations reporting significant incidence rates. The most representative of those were the MYD88 (L256P) mutation with an incidence rate of 81% and 6q deletion with an incidence rate of 36%. In addition, CXCR4 mutation, 13q14 deletion and trisomy 4 showed an incidence rate of 29%, 12% and 14%, respectively. Finally, the deletion 17p13 was present in 8% of subjects. Our results suggest that the MYD88 (L256P) mutation might be a target for the development of specific therapeutic strategies.
000136372 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI15-00558
000136372 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000136372 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136372 700__ $$aRueda-González, Jesús
000136372 700__ $$aMartín-Hernández, Juan
000136372 700__ $$aSerna-Molpereces, Jorge
000136372 700__ $$aCristi-Montero, Carlos
000136372 700__ $$aFiuza-Luces, Carmen
000136372 700__ $$aBaladrón, Carlos
000136372 700__ $$aPinto-Fraga, José
000136372 700__ $$0(orcid)0000-0001-8374-9081$$aGaratachea, Nuria$$uUniversidad de Zaragoza
000136372 700__ $$aCedena, María Teresa
000136372 700__ $$aMartínez-López, Joaquín
000136372 700__ $$aLucia, Alejandro
000136372 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000136372 773__ $$g4, 1 (2019), [7 pp.]$$pHematol. Med. Oncol.$$tHematology & Medical Oncology$$x2398-8495
000136372 8564_ $$s806538$$uhttps://zaguan.unizar.es/record/136372/files/texto_completo.pdf$$yVersión publicada
000136372 8564_ $$s2732967$$uhttps://zaguan.unizar.es/record/136372/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000136372 909CO $$ooai:zaguan.unizar.es:136372$$particulos$$pdriver
000136372 951__ $$a2024-07-31-09:23:55
000136372 980__ $$aARTICLE