Parental history of dementia and the risk of dementia: A cross-sectional analysis of a global collaborative study

Oh, Dae Jong ; Bae, Jong Bin ; Lipnicki, Darren M. ; Han, Ji Won ; Sachdev, Perminder S. ; Kim, Tae Hui ; Kwak, Kyung Phil ; Kim, Bong Jo ; Kim, Shin Gyeom ; Kim, Jeong Lan ; Moon, Seok Woo ; Park, Joon Hyuk ; Ryu, Seung-Ho ; Youn, Jong Chul ; Lee, Dong Young ; Lee, Dong Woo ; Lee, Seok Bum ; Lee, Jung Jae ; Jhoo, Jin Hyeong ; Skoog, Ingmar ; Najar, Jenna ; Sterner, Therese R. ; Guaita, Antonio ; Vaccaro, Roberta ; Rolandi, Elena ; Scarmeas, Nikolaos ; Yannakoulia, Mary ; Kosmidis, Mary H. ; Riedel-Heller, Steffi G. ; Roehr, Susanne ; Dominguez, Jacqueline ; De Guzman, Ma Fe ; Fowler, Krizelle Cleo ; Lobo, Antonio (Universidad de Zaragoza) ; Saz, Pedro (Universidad de Zaragoza) ; López-Antón, Raúl (Universidad de Zaragoza) ; Anstey, Kaarin J. ; Cherbuin, Nicolas ; Mortby, Moyra E. ; Brodaty, Henry ; Trollor, Julian ; Kochan, Nicole ; Kim, Ki Woong ;

Resumen: Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring.MethodsFor this cross‐sectional study, we harmonized and pooled data for 17,194 older adults from nine population‐based cohorts of eight countries. These studies conducted face‐to‐face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring.ResultsThe mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15–1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31–2.26), but not with the risk of non‐AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15–1.97) and AD (OR = 1.80, 95% CI = 1.33–2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28–3.55 in males; OR = 1.68, 95% CI = 1.16–2.44 for females).ConclusionsMaternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials.

Idioma: Inglés

DOI: 10.1111/pcn.13561

Año: 2023

Publicado en: PSYCHIATRY AND CLINICAL NEUROSCIENCES 77, 8 (2023), 449-456
ISSN: 1323-1316

Factor impacto JCR: 5.0 (2023)

Categ. JCR: CLINICAL NEUROLOGY rank: 32 / 280 = 0.114 (2023) - Q1 - T1
Categ. JCR: PSYCHIATRY rank: 35 / 279 = 0.125 (2023) - Q1 - T1
Categ. JCR: NEUROSCIENCES rank: 49 / 310 = 0.158 (2023) - Q1 - T1

Factor impacto CITESCORE: 7.4 - Psychiatry and Mental Health (Q1) - Neurology (Q1) - Neurology (clinical) (Q1) - Neuroscience (all) (Q2)

Factor impacto SCIMAGO: 1.25 - Medicine (miscellaneous) (Q1) - Neurology (Q1) - Psychiatry and Mental Health (Q1) - Neuroscience (miscellaneous) (Q1) - Neurology (clinical) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B15-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E

Tipo y forma: Article (Published version)

Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)