000145252 001__ 145252
000145252 005__ 20241015122513.0
000145252 0247_ $$2doi$$a10.1016/j.isci.2024.110839
000145252 0248_ $$2sideral$$a140025
000145252 037__ $$aART-2024-140025
000145252 041__ $$aeng
000145252 100__ $$0(orcid)0000-0001-6565-9699$$aOliván-Blázquez, Bárbara$$uUniversidad de Zaragoza
000145252 245__ $$aCharacterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers
000145252 260__ $$c2024
000145252 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145252 5203_ $$aPost-coronavirus disease condition (PCC) continues to affect many people globally, yet there remains a lack of diagnostic biomarkers to distinguish PCC from those recovered from acute COVID-19. This study compared biomarkers between two age- and gender-matched groups: PCC individuals and those recovered within three months of acute COVID-19 in 2020 (n = 85 each). Biomarkers were assessed 12–24 months after initial diagnosis, examining biochemical profiles, blood cell counts, coagulation status, antibody serology, lymphocyte populations, and cytokine levels. PCC individuals exhibited significant alterations in 49 of 167 markers, including K+ levels, αGAD antibodies, antithrombin III, insulin-like growth factor-binding protein 3 (IGFBP3), and interleukin-10 (IL-10). A panel of αGAD, IL-10, potassium levels, and CD16brightCD56− cell presence distinguished PCC individuals from recovered patients with >88% accuracy and <92% precision.
000145252 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B21-23R-GAIAP$$9info:eu-repo/grantAgreement/ES/DGA/B46-20R$$9info:eu-repo/grantAgreement/EC/H2020/101057302 /EU/SARS-CoV-2-induced activation of pathogenic endogenous retrovirus envelope HERV-W: towards personalized treatment of COVID-19 patients/HERVCOV$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101057302 -HERVCOV$$9info:eu-repo/grantAgreement/ES/IACS/PT20-00112$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01070$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0005
000145252 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000145252 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145252 700__ $$aBona-Otal, Marta
000145252 700__ $$0(orcid)0000-0002-6409-9041$$aMéndez-López, Fátima$$uUniversidad de Zaragoza
000145252 700__ $$0(orcid)0000-0002-0660-218X$$aLerma-Irureta, David
000145252 700__ $$aGarcía-Izuel, Paula
000145252 700__ $$aIbáñez-Ruiz, Jesús
000145252 700__ $$0(orcid)0000-0001-7248-4399$$aMontolío, Alberto
000145252 700__ $$aRuiz-Herreros, María
000145252 700__ $$aGodino, Javier
000145252 700__ $$aJimeno-Beltran, Beatriz
000145252 700__ $$0(orcid)0000-0003-4891-105X$$aEncabo-Berzosa, María del Mar
000145252 700__ $$aArenaz, Izaskun
000145252 700__ $$aMedel-Martínez, Ana
000145252 700__ $$aCasado-Vicente, Verónica
000145252 700__ $$aCoiras, Mayte
000145252 700__ $$0(orcid)0000-0002-6394-3212$$aTellería-Orriols, Carlos$$uUniversidad de Zaragoza
000145252 700__ $$aSchoorlemmer, Jon
000145252 700__ $$0(orcid)0000-0002-5494-6550$$aMagallón-Botaya, Rosa$$uUniversidad de Zaragoza
000145252 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000145252 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social
000145252 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000145252 7102_ $$15007$$2570$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Lenguajes y Sistemas Inf.
000145252 773__ $$g27, 9 (2024), 110839 [16 pp.]$$piScience$$tISCIENCE$$x2589-0042
000145252 8564_ $$s3596569$$uhttps://zaguan.unizar.es/record/145252/files/texto_completo.pdf$$yVersión publicada
000145252 8564_ $$s1084401$$uhttps://zaguan.unizar.es/record/145252/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145252 909CO $$ooai:zaguan.unizar.es:145252$$particulos$$pdriver
000145252 951__ $$a2024-10-15-10:50:53
000145252 980__ $$aARTICLE