Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers

Oliván-Blázquez, Bárbara (Universidad de Zaragoza) ; Bona-Otal, Marta ; Méndez-López, Fátima (Universidad de Zaragoza) ; Lerma-Irureta, David ; García-Izuel, Paula ; Ibáñez-Ruiz, Jesús ; Montolío, Alberto ; Ruiz-Herreros, María ; Godino, Javier ; Jimeno-Beltran, Beatriz ; Encabo-Berzosa, María del Mar ; Arenaz, Izaskun ; Medel-Martínez, Ana ; Casado-Vicente, Verónica ; Coiras, Mayte ; Tellería-Orriols, Carlos (Universidad de Zaragoza) ; Schoorlemmer, Jon ; Magallón-Botaya, Rosa (Universidad de Zaragoza)

Resumen: Post-coronavirus disease condition (PCC) continues to affect many people globally, yet there remains a lack of diagnostic biomarkers to distinguish PCC from those recovered from acute COVID-19. This study compared biomarkers between two age- and gender-matched groups: PCC individuals and those recovered within three months of acute COVID-19 in 2020 (n = 85 each). Biomarkers were assessed 12–24 months after initial diagnosis, examining biochemical profiles, blood cell counts, coagulation status, antibody serology, lymphocyte populations, and cytokine levels. PCC individuals exhibited significant alterations in 49 of 167 markers, including K+ levels, αGAD antibodies, antithrombin III, insulin-like growth factor-binding protein 3 (IGFBP3), and interleukin-10 (IL-10). A panel of αGAD, IL-10, potassium levels, and CD16brightCD56− cell presence distinguished PCC individuals from recovered patients with >88% accuracy and <92% precision.

Idioma: Inglés

DOI: 10.1016/j.isci.2024.110839

Año: 2024

Publicado en: ISCIENCE 27, 9 (2024), 110839 [16 pp.]
ISSN: 2589-0042

Financiación: info:eu-repo/grantAgreement/ES/DGA/B21-23R-GAIAP
Financiación: info:eu-repo/grantAgreement/ES/DGA/B46-20R
Financiación: info:eu-repo/grantAgreement/EC/H2020/101057302 /EU/SARS-CoV-2-induced activation of pathogenic endogenous retrovirus envelope HERV-W: towards personalized treatment of COVID-19 patients/HERVCOV
Financiación: info:eu-repo/grantAgreement/ES/IACS/PT20-00112
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI22-01070
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0005

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Psicología Social (Dpto. Psicología y Sociología)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Lenguajes y Sistemas Inf. (Dpto. Informát.Ingenie.Sistms.)