Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers
Financiación H2020 / H2020 Funds
Resumen: Post-coronavirus disease condition (PCC) continues to affect many people globally, yet there remains a lack of diagnostic biomarkers to distinguish PCC from those recovered from acute COVID-19. This study compared biomarkers between two age- and gender-matched groups: PCC individuals and those recovered within three months of acute COVID-19 in 2020 (n = 85 each). Biomarkers were assessed 12–24 months after initial diagnosis, examining biochemical profiles, blood cell counts, coagulation status, antibody serology, lymphocyte populations, and cytokine levels. PCC individuals exhibited significant alterations in 49 of 167 markers, including K+ levels, αGAD antibodies, antithrombin III, insulin-like growth factor-binding protein 3 (IGFBP3), and interleukin-10 (IL-10). A panel of αGAD, IL-10, potassium levels, and CD16brightCD56− cell presence distinguished PCC individuals from recovered patients with >88% accuracy and <92% precision.
Idioma: Inglés
DOI: 10.1016/j.isci.2024.110839
Año: 2024
Publicado en: ISCIENCE 27, 9 (2024), 110839 [16 pp.]
ISSN: 2589-0042

Financiación: info:eu-repo/grantAgreement/ES/DGA/B21-23R-GAIAP
Financiación: info:eu-repo/grantAgreement/ES/DGA/B46-20R
Financiación: info:eu-repo/grantAgreement/EC/H2020/101057302 /EU/SARS-CoV-2-induced activation of pathogenic endogenous retrovirus envelope HERV-W: towards personalized treatment of COVID-19 patients/HERVCOV
Financiación: info:eu-repo/grantAgreement/ES/IACS/PT20-00112
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI22-01070
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0005
Tipo y forma: Article (Published version)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Psicología Social (Dpto. Psicología y Sociología)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Lenguajes y Sistemas Inf. (Dpto. Informát.Ingenie.Sistms.)

Exportado de SIDERAL (2024-10-15-10:50:53)


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Este artículo se encuentra en las siguientes colecciones:
articulos > articulos-por-area > lenguajes_y_sistemas_informaticos
articulos > articulos-por-area > psicologia_social
articulos > articulos-por-area > enfermeria
articulos > articulos-por-area > medicina



 Notice créée le 2024-10-15, modifiée le 2024-10-15


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