000145327 001__ 145327 000145327 005__ 20241024135330.0 000145327 0247_ $$2doi$$a10.3390/nu13072167 000145327 0248_ $$2sideral$$a126880 000145327 037__ $$aART-2021-126880 000145327 041__ $$aeng 000145327 100__ $$0(orcid)0000-0001-5990-1266$$aBlanco Gandía M.C.$$uUniversidad de Zaragoza 000145327 245__ $$aKetogenic diet decreases alcohol intake in adult male mice 000145327 260__ $$c2021 000145327 5060_ $$aAccess copy available to the general public$$fUnrestricted 000145327 5203_ $$aThe classic ketogenic diet is a diet high in fat, low in carbohydrates, and well-adjusted proteins. The reduction in glucose levels induces changes in the body’s metabolism, since the main energy source happens to be ketone bodies. Recent studies have suggested that nutritional interventions may modulate drug addiction. The present work aimed to study the potential effects of a classic ketogenic diet in modulating alcohol consumption and its rewarding effects. Two groups of adult male mice were employed in this study, one exposed to a standard diet (SD, n = 15) and the other to a ketogenic diet (KD, n = 16). When a ketotic state was stable for 7 days, animals were exposed to the oral self-administration paradigm to evaluate the reinforcing and motivating effects of ethanol. Rt-PCR analyses were performed evaluating dopamine, adenosine, CB1, and Oprm gene expression. Our results showed that animals in a ketotic state displayed an overall decrease in ethanol consumption without changes in their motivation to drink. Gene expression analyses point to several alterations in the dopamine, adenosine, and cannabinoid systems. Our results suggest that nutritional interventions may be a useful complementary tool in treating alcohol-use disorders. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. 000145327 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0004$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007 000145327 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000145327 590__ $$a6.706$$b2021 000145327 591__ $$aNUTRITION & DIETETICS$$b15 / 90 = 0.167$$c2021$$dQ1$$eT1 000145327 592__ $$a1.287$$b2021 000145327 593__ $$aNutrition and Dietetics$$c2021$$dQ1 000145327 593__ $$aFood Science$$c2021$$dQ1 000145327 594__ $$a7.9$$b2021 000145327 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000145327 700__ $$aRódenas-González F. 000145327 700__ $$aPascual M. 000145327 700__ $$aReguilón M.D. 000145327 700__ $$aGuerri C. 000145327 700__ $$aMiñarro J. 000145327 700__ $$aRodríguez-Arias M. 000145327 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000145327 773__ $$g13, 7 (2021), 2167 [16 pp]$$pNutrients$$tNutrients$$x2072-6643 000145327 8564_ $$s2023660$$uhttps://zaguan.unizar.es/record/145327/files/texto_completo.pdf$$yVersión publicada 000145327 8564_ $$s2771207$$uhttps://zaguan.unizar.es/record/145327/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000145327 909CO $$ooai:zaguan.unizar.es:145327$$particulos$$pdriver 000145327 951__ $$a2024-10-24-12:10:27 000145327 980__ $$aARTICLE