000145574 001__ 145574
000145574 005__ 20250923084440.0
000145574 0247_ $$2doi$$a10.1016/j.heliyon.2024.e39350
000145574 0248_ $$2sideral$$a140378
000145574 037__ $$aART-2024-140378
000145574 041__ $$aeng
000145574 100__ $$aAdwan, Lara
000145574 245__ $$aInterfacial insights: [6]-Gingerol monolayers at the air-water interface and beyond
000145574 260__ $$c2024
000145574 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145574 5203_ $$aGinger is a culinary spice with a millennia-old tradition due to its extensive therapeutic applications, recently validated by scientific studies. In particular [6]-Gingerol, a key active molecule in ginger, exhibits extraordinary capabilities in addressing a wide spectrum of health issues. However, its therapeutic potential is limited by its rather low bioavailability. The incorporation of [6]-Gingerol into membrane systems of liposomes, micelles, or exosomes is a promising strategy to overcome this limitation. In this contribution, we report the hitherto unexplored surface properties of [6]-Gingerol at the air-water interface. Our comprehensive study, which includes a detailed analysis of surface pressure and surface potential vs. area per molecule isotherms, surface compression modulus, and Brewster Angle Microscopy, demonstrates the capability of [6]-Gingerol to form Langmuir films. These films can be transferred onto solid substrates, forming remarkably homogeneous Langmuir-Blodgett films which have been characterized by Quartz Crystal Microbalance and Atomic Force Microscopy. This study may be of interest as it paves the way for future research on introducing [6]-Gingerol into membrane systems and transporting it into living cells.
000145574 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E31-23R
000145574 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000145574 590__ $$a3.6$$b2024
000145574 592__ $$a0.644$$b2024
000145574 591__ $$aMULTIDISCIPLINARY SCIENCES$$b29 / 135 = 0.215$$c2024$$dQ1$$eT1
000145574 593__ $$aMultidisciplinary$$c2024$$dQ1
000145574 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145574 700__ $$aDotor, Laura$$uUniversidad de Zaragoza
000145574 700__ $$aPino, María Graciela
000145574 700__ $$aGil, Adriana
000145574 700__ $$0(orcid)0000-0001-9193-3874$$aMartin, Santiago$$uUniversidad de Zaragoza
000145574 700__ $$0(orcid)0000-0002-4729-9578$$aCea, Pilar$$uUniversidad de Zaragoza
000145574 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000145574 773__ $$g10, 20 (2024), e39350 [9 pp.]$$pHeliyon$$tHeliyon$$x2405-8440
000145574 8564_ $$s5464520$$uhttps://zaguan.unizar.es/record/145574/files/texto_completo.pdf$$yVersión publicada
000145574 8564_ $$s1956871$$uhttps://zaguan.unizar.es/record/145574/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145574 909CO $$ooai:zaguan.unizar.es:145574$$particulos$$pdriver
000145574 951__ $$a2025-09-22-14:50:21
000145574 980__ $$aARTICLE