Interfacial insights: [6]-Gingerol monolayers at the air-water interface and beyond

Adwan, Lara ; Dotor, Laura (Universidad de Zaragoza) ; Pino, María Graciela ; Gil, Adriana ; Martin, Santiago (Universidad de Zaragoza) ; Cea, Pilar (Universidad de Zaragoza)

Resumen: Ginger is a culinary spice with a millennia-old tradition due to its extensive therapeutic applications, recently validated by scientific studies. In particular [6]-Gingerol, a key active molecule in ginger, exhibits extraordinary capabilities in addressing a wide spectrum of health issues. However, its therapeutic potential is limited by its rather low bioavailability. The incorporation of [6]-Gingerol into membrane systems of liposomes, micelles, or exosomes is a promising strategy to overcome this limitation. In this contribution, we report the hitherto unexplored surface properties of [6]-Gingerol at the air-water interface. Our comprehensive study, which includes a detailed analysis of surface pressure and surface potential vs. area per molecule isotherms, surface compression modulus, and Brewster Angle Microscopy, demonstrates the capability of [6]-Gingerol to form Langmuir films. These films can be transferred onto solid substrates, forming remarkably homogeneous Langmuir-Blodgett films which have been characterized by Quartz Crystal Microbalance and Atomic Force Microscopy. This study may be of interest as it paves the way for future research on introducing [6]-Gingerol into membrane systems and transporting it into living cells.

Idioma: Inglés

DOI: 10.1016/j.heliyon.2024.e39350

Año: 2024

Publicado en: Heliyon 10, 20 (2024), e39350 [9 pp.]
ISSN: 2405-8440

Factor impacto JCR: 3.6 (2024)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 29 / 135 = 0.215 (2024) - Q1 - T1

Factor impacto SCIMAGO: 0.644 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E31-23R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Química Física (Dpto. Química Física)