Hypoxaemic load in sleep apnoea is associated with acute changes in T-wave amplitude
Sillanmäki, Saara ; Ebrahimian, Serajeddin ; Hietakoste, Salla ; Hernando, David ; Bailon, Raquel (Universidad de Zaragoza) ; Leppänen, Timo ; Kainulainen, Samu
Resumen: AimsObstructive sleep apnoea (OSA) imposes significant stress on the cardiovascular system and the heart. While long-term cardiac effects are understood, the immediate impact of hypoxaemia on the heart's electrophysiology lacks understanding. Our study aims to explore desaturation severity on cardiovascular repolarisation.MethodsWe retrospectively analysed ECGs from full diagnostic polysomnographies from 492 patients with suspected OSA. The analyses were conducted before, during and after 9137 nocturnal apnoea- or hypopnoea-related desaturations. The mean andsdof T-wave amplitude change from the baseline level to the level during and after desaturations (ΔTamp_meanand ΔTamp_SD) were calculated. To investigate the modulatory effects of desaturation severity, the data were divided into subgroups based on the desaturation duration (Tdes; 10 s≤Tdes<20 s, 20 s≤Tdes<30 s, 30 s≤Tdes<45 s and Tdes≥45 s) and magnitude of blood oxygen saturation drop (change in peripheral oxygen saturation (ΔSpO2); 3%≤ΔSpO2<4.5%, 4.5%≤ΔSpO2<6%, 6%≤ΔSpO2<7.5% and ΔSpO2≥7.5%) for men and women.ResultsDesaturations caused significant (p<0.01) changes in ΔTamp_meanduring and after desaturations. In men, the median ΔTamp_meanduring and after deep (ΔSpO2≥7.5%) desaturations were 21 µV and 24 µV, respectively. In women, the median ΔTamp_meanin deep desaturations was 15 µV during and 21 µV after desaturations. Similarly, the ΔTamp_SDincreased during and after deep desaturations. In regression analysis, the desaturation depth was an independent predictor for ventricular repolarisation instability.ConclusionWe found an association between the severity of nocturnal desaturations and cardiac repolarisation instability. These findings hold particular importance, as repolarisation instability has been linked with cardiovascular morbidity and could potentially serve as a trigger for arrhythmias and sudden cardiac death.
Idioma: Inglés
DOI: 10.1183/23120541.00341-2024
Año: 2024
Publicado en: ERJ Open Research 10, 5 (2024), 00341-2024
ISSN: 2312-0541
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group
Financiación: info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-126734OB-C21
Tipo y forma: Article (Published version)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2024-12-16-11:28:24)
Visitas y descargas
Idioma: Inglés
DOI: 10.1183/23120541.00341-2024
Año: 2024
Publicado en: ERJ Open Research 10, 5 (2024), 00341-2024
ISSN: 2312-0541
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group
Financiación: info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-126734OB-C21
Tipo y forma: Article (Published version)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-12-16-11:28:24)
Permalink:
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Teoría de la Señal y Comunicaciones
Record created 2024-12-16, last modified 2024-12-16