Comorbidities and mortality risk in adults younger than 50 years of age with chronic obstructive pulmonary disease
Divo, Miguel J. ; Marin, José M. (Universidad de Zaragoza) ; Casanova, Ciro ; Cabrera Lopez, Carlos ; Pinto-Plata, Victor M. ; Marin-Oto, Marta (Universidad de Zaragoza) ; Polverino, Francesca ; de-Torres, Juan P. ; Billheimer, Dean ; Celli, Bartolome R. ; Celli, Bartolome R. ; Marin, José M. ; Macario, Ciro Casanova ; Pinto-Plata, Victor ; de-Torres, Juan Pablo ; Divo, Miguel J. ; Lopez, Carlos Cabrera ; Polverino, Francesca ; Oto, Marta Marin
Resumen: Abstract
Rationale and objective: Patients with chronic obstructive pulmonary disease (COPD), usually diagnosed after the 6th decade, frequently suffer from comorbidities. Whether COPD patients 50 years or younger (Young COPD) have similar comorbidities with the same frequency and mortality impact as aged-matched controls or older COPD patients is unknown.
Methods
We compared comorbidity number, prevalence and type in 3 groups of individuals with ≥ 10 pack-years of smoking: A Young (≤ 50 years) COPD group (n = 160), an age-balanced control group without airflow obstruction (n = 125), and Old (> 50 years) COPD group (n = 1860). We also compared survival between the young COPD and control subjects. Using Cox proportional model, we determined the comorbidities associated with mortality risk and generated Comorbidomes for the “Young” and “Old” COPD groups.
Results
The severity distribution by GOLD spirometric stages and BODE quartiles were similar between Young and Old COPD groups. After adjusting for age, sex, and pack-years, the prevalence of subjects with at least one comorbidity was 31% for controls, 77% for the Young, and 86% for older COPD patients. Compared to controls, “Young” COPDs’ had a nine-fold increased mortality risk (p < 0.0001). “Comorbidomes” differed between Young and Old COPD groups, with tuberculosis, substance use, and bipolar disorders being distinct comorbidities associated with increased mortality risk in the Young COPD group.
Conclusions
Young COPD patients carry a higher comorbidity prevalence and mortality risk compared to non-obstructed control subjects. Young COPD differed from older COPD patients by the behavioral-related comorbidities that increase their risk of premature death.
Idioma: Inglés
DOI: 10.1186/s12931-022-02191-7
Año: 2022
Publicado en: Respiratory Research 23, 1 (2022), 267 [10 pp.]
ISSN: 1465-9921
Factor impacto JCR: 5.8 (2022)
Categ. JCR: RESPIRATORY SYSTEM rank: 15 / 66 = 0.227 (2022) - Q1 - T1
Factor impacto CITESCORE: 9.5 - Medicine (Q1)
Factor impacto SCIMAGO: 1.753 - Pulmonary and Respiratory Medicine (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2025-01-09-14:41:20)
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Rationale and objective: Patients with chronic obstructive pulmonary disease (COPD), usually diagnosed after the 6th decade, frequently suffer from comorbidities. Whether COPD patients 50 years or younger (Young COPD) have similar comorbidities with the same frequency and mortality impact as aged-matched controls or older COPD patients is unknown.
Methods
We compared comorbidity number, prevalence and type in 3 groups of individuals with ≥ 10 pack-years of smoking: A Young (≤ 50 years) COPD group (n = 160), an age-balanced control group without airflow obstruction (n = 125), and Old (> 50 years) COPD group (n = 1860). We also compared survival between the young COPD and control subjects. Using Cox proportional model, we determined the comorbidities associated with mortality risk and generated Comorbidomes for the “Young” and “Old” COPD groups.
Results
The severity distribution by GOLD spirometric stages and BODE quartiles were similar between Young and Old COPD groups. After adjusting for age, sex, and pack-years, the prevalence of subjects with at least one comorbidity was 31% for controls, 77% for the Young, and 86% for older COPD patients. Compared to controls, “Young” COPDs’ had a nine-fold increased mortality risk (p < 0.0001). “Comorbidomes” differed between Young and Old COPD groups, with tuberculosis, substance use, and bipolar disorders being distinct comorbidities associated with increased mortality risk in the Young COPD group.
Conclusions
Young COPD patients carry a higher comorbidity prevalence and mortality risk compared to non-obstructed control subjects. Young COPD differed from older COPD patients by the behavioral-related comorbidities that increase their risk of premature death.
Idioma: Inglés
DOI: 10.1186/s12931-022-02191-7
Año: 2022
Publicado en: Respiratory Research 23, 1 (2022), 267 [10 pp.]
ISSN: 1465-9921
Factor impacto JCR: 5.8 (2022)
Categ. JCR: RESPIRATORY SYSTEM rank: 15 / 66 = 0.227 (2022) - Q1 - T1
Factor impacto CITESCORE: 9.5 - Medicine (Q1)
Factor impacto SCIMAGO: 1.753 - Pulmonary and Respiratory Medicine (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2025-01-09-14:41:20)
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Record created 2025-01-09, last modified 2025-01-09