000147905 001__ 147905
000147905 005__ 20250109162738.0
000147905 0247_ $$2doi$$a10.3390/ijms241814250
000147905 0248_ $$2sideral$$a141355
000147905 037__ $$aART-2023-141355
000147905 041__ $$aeng
000147905 100__ $$aCallejón-Leblic, Belén
000147905 245__ $$aMetallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease
000147905 260__ $$c2023
000147905 5060_ $$aAccess copy available to the general public$$fUnrestricted
000147905 5203_ $$aLung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.
000147905 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000147905 590__ $$a4.9$$b2023
000147905 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b66 / 313 = 0.211$$c2023$$dQ1$$eT1
000147905 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b68 / 231 = 0.294$$c2023$$dQ2$$eT1
000147905 592__ $$a1.179$$b2023
000147905 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000147905 593__ $$aPhysical and Theoretical Chemistry$$c2023$$dQ1
000147905 593__ $$aComputer Science Applications$$c2023$$dQ1
000147905 593__ $$aInorganic Chemistry$$c2023$$dQ1
000147905 593__ $$aSpectroscopy$$c2023$$dQ1
000147905 593__ $$aOrganic Chemistry$$c2023$$dQ1
000147905 593__ $$aMolecular Biology$$c2023$$dQ2
000147905 593__ $$aCatalysis$$c2023$$dQ2
000147905 594__ $$a8.1$$b2023
000147905 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000147905 700__ $$aSánchez Espirilla, Saida
000147905 700__ $$aGotera-Rivera, Carolina
000147905 700__ $$aSantana, Rafael
000147905 700__ $$aDíaz-Olivares, Isabel
000147905 700__ $$0(orcid)0000-0001-9096-2294$$aMarín, José M.$$uUniversidad de Zaragoza
000147905 700__ $$aMacario, Ciro Casanova
000147905 700__ $$aCosio, Borja García
000147905 700__ $$aFuster, Antonia
000147905 700__ $$aGarcía, Ingrid Solanes
000147905 700__ $$ade-Torres, Juan P.
000147905 700__ $$aFeu Collado, Nuria
000147905 700__ $$aCabrera Lopez, Carlos
000147905 700__ $$aAmado Diago, Carlos
000147905 700__ $$aRomero Plaza, Amparo
000147905 700__ $$aFraysse, Luis Alejandro Padrón
000147905 700__ $$aMárquez Martín, Eduardo
000147905 700__ $$aMarín Royo, Margarita
000147905 700__ $$aBalcells Vilarnau, Eva
000147905 700__ $$aLlunell Casanovas, Antonia
000147905 700__ $$aMartínez González, Cristina
000147905 700__ $$aGaldíz Iturri, Juan Bautista
000147905 700__ $$aLacárcel Bautista, Celia
000147905 700__ $$aGómez-Ariza, José Luis
000147905 700__ $$aPereira-Vega, Antonio
000147905 700__ $$aSeijo, Luis
000147905 700__ $$aLópez-Campos, José Luis
000147905 700__ $$aPeces-Barba, Germán
000147905 700__ $$aGarcía-Barrera, Tamara
000147905 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000147905 773__ $$g24, 18 (2023), 14250 [14 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000147905 8564_ $$s3577301$$uhttps://zaguan.unizar.es/record/147905/files/texto_completo.pdf$$yVersión publicada
000147905 8564_ $$s2868670$$uhttps://zaguan.unizar.es/record/147905/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000147905 909CO $$ooai:zaguan.unizar.es:147905$$particulos$$pdriver
000147905 951__ $$a2025-01-09-14:41:36
000147905 980__ $$aARTICLE