Quantitative Determination of 22 Primary Aromatic Amines by Cation-Exchange Solid-Phase Extraction and Liquid Chromatography-Mass Spectrometry

Aznar, M. (Universidad de Zaragoza) ; Canellas, E. (Universidad de Zaragoza) ; Nerin, C. (Universidad de Zaragoza)

Resumen: Primary aromatic amines (PAAs) have been broadly studied due to their high toxicity. In this work a method for the analysis of 22 PAAs in aqueous simulants has been developed. The method is based on a solid-phase extraction step using cation-exchange cartridges and the subsequent analysis of the extracts by ultra-high-performance liquid chromatography with mass spectrometric detection. The recoveries obtained for all the amines analyzed ranged between 81 and 109%, linear range was between 0.03 and 75 μg L−1, with the RSD values between 4.5 and 13.4% and an average value of 7.5% and limits of detection at μg L−1 level. The method has been applied to two real samples obtained from migration experiments of polyurethane based laminates to simulant B (water with 3% (w/v) acetic acid) which represents the worst case for the migration of aromatic amines. The main amines found in both samples were methylenedianiline isomers, obtained from the corresponding residual diisocyanates used during polyurethane adhesive polymerization. The total amine concentration found was 26 and 6.3 μg of aniline equivalents per kg of food simulant.

Idioma: Inglés

Año: 2009

Publicado en: Journal of Chromatography A 1216, 27 (2009), 5176-5181
ISSN: 0021-9673

Factor impacto JCR: 4.101 (2009)

Categ. JCR: CHEMISTRY, ANALYTICAL rank: 4 / 70 = 0.057 (2009) - Q1 - T1
Categ. JCR: BIOCHEMICAL RESEARCH METHODS rank: 13 / 67 = 0.194 (2009) - Q1 - T1

Financiación: info:eu-repo/grantAgreement/ES/MEC/PET2006_0512_00

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Química Analítica (Dpto. Química Analítica)
Área (Departamento): Proy. investigación HVA (Dpto. Química Analítica)