000148187 001__ 148187 000148187 005__ 20250114175434.0 000148187 0247_ $$2doi$$a10.1007/s00394-022-02823-0 000148187 0248_ $$2sideral$$a131413 000148187 037__ $$aART-2022-131413 000148187 041__ $$aeng 000148187 100__ $$aSalazar, Henry Montero 000148187 245__ $$aThe intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium 000148187 260__ $$c2022 000148187 5060_ $$aAccess copy available to the general public$$fUnrestricted 000148187 5203_ $$aPurpose It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects. MethodsUltrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between 2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium. Results A higher intake of flavonoids (third vs. first tertile) was associated with a lower risk of both carotid (OR 0.80: CI 95% 0.62–1.02; P trend 0.094) and femoral (0.62: 0.48–0.80, P trend < 0.001) subclinical atherosclerosis. A higher intake of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46–0.83; P trend 0.009) and positive coronary calcium (0.75: 0.55–1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk of positive coronary calcium (0.80: 0.62–1.03; P trend 0.111). The associations remained similar when adjusted for blood lipids and blood pressure. Conclusion Dietary flavonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated with lower prevalence of subclinical atherosclerosis in middle-aged subjects. 000148187 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PIE16-00022$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI17-1709$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20/144 000148187 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000148187 590__ $$a5.0$$b2022 000148187 591__ $$aNUTRITION & DIETETICS$$b28 / 87 = 0.322$$c2022$$dQ2$$eT1 000148187 592__ $$a1.094$$b2022 000148187 593__ $$aNutrition and Dietetics$$c2022$$dQ1 000148187 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1 000148187 594__ $$a9.7$$b2022 000148187 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000148187 700__ $$ade Deus Mendonça, Raquel 000148187 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza 000148187 700__ $$aMoreno-Franco, Belén 000148187 700__ $$aÅkesson, Agneta 000148187 700__ $$aGuallar-Castillón, Pilar 000148187 700__ $$aDonat-Vargas, Carolina 000148187 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000148187 773__ $$g61, 5 (2022), 2697-2709$$pEur. j. nutr.$$tEUROPEAN JOURNAL OF NUTRITION$$x1436-6207 000148187 8564_ $$s529060$$uhttps://zaguan.unizar.es/record/148187/files/texto_completo.pdf$$yVersión publicada 000148187 8564_ $$s2115999$$uhttps://zaguan.unizar.es/record/148187/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000148187 909CO $$ooai:zaguan.unizar.es:148187$$particulos$$pdriver 000148187 951__ $$a2025-01-14-15:49:07 000148187 980__ $$aARTICLE