000148330 001__ 148330
000148330 005__ 20250116161253.0
000148330 0247_ $$2doi$$a10.1039/c4sc01684j
000148330 0248_ $$2sideral$$a87943
000148330 037__ $$aART-2014-87943
000148330 041__ $$aeng
000148330 100__ $$0(orcid)0000-0002-1218-7218$$aFernández-Moreira, Vanesa$$uUniversidad de Zaragoza
000148330 245__ $$aLuminescent Re(i) and Re(i)/Au(i) complexes as cooperative partners in cell imaging and cancer therapy
000148330 260__ $$c2014
000148330 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148330 5203_ $$aA series of luminescent monometallic fac-[Re(bipy)(CO)3(L)]+ and heterometallic fac-[Re(bipy)(CO)3(L-AuPPh3)]+ complexes, where L is an imidazole, alkynyl-imidazole or alkynyl-pyridine derivative, have been synthesised for the purpose of finding a synergic effect between the excellent photophysical properties of rhenium complexes and the good antiproliferative effects of gold compounds. Cytotoxicity studies performed in human A549 lung cancer cells revealed the importance of the alkynyl–phosphine–gold fragment within the probe to design efficient anticancer agents. Heterometallic Re(I)/Au(I) derivatives presented values of IC50 more than 10 times lower than their analogous Re(I) complexes. In addition, fluorescent cell microscopy pointed out the different biodistribution behaviour of the monometallic and heterometallic families. Whereas the monometallic Re(I) species showed some general cytoplasmatic staining with mitochondrial accumulation, the heterometallic Re(I)/Au(I) derivatives shifted from localising in the mitochondria to the nucleus and nucleolus upon increasing the loading concentration, suggesting a completely different driving force for their localisation pattern. These facts revealed that these bimetallic species can be excellent partners in cell imaging and cancer therapy.
000148330 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/B16$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E77$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2010-20500-C02-0$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/SAF2010-14920
000148330 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000148330 590__ $$a9.211$$b2014
000148330 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b14 / 154 = 0.091$$c2014$$dQ1$$eT1
000148330 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148330 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo, Isabel$$uUniversidad de Zaragoza
000148330 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción$$uUniversidad de Zaragoza
000148330 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000148330 7102_ $$12010$$2X$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cProy. investigación HWA
000148330 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000148330 773__ $$g5, 11 (2014), 4434-4446$$pChem. sci.$$tCHEMICAL SCIENCE$$x2041-6520
000148330 8564_ $$s1190479$$uhttps://zaguan.unizar.es/record/148330/files/texto_completo.pdf$$yPostprint
000148330 8564_ $$s2705127$$uhttps://zaguan.unizar.es/record/148330/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148330 909CO $$ooai:zaguan.unizar.es:148330$$particulos$$pdriver
000148330 951__ $$a2025-01-16-14:31:25
000148330 980__ $$aARTICLE