Luminescent Re(i) and Re(i)/Au(i) complexes as cooperative partners in cell imaging and cancer therapy

Fernández-Moreira, Vanesa (Universidad de Zaragoza) ; Marzo, Isabel (Universidad de Zaragoza) ; Gimeno, M. Concepción (Universidad de Zaragoza)

Resumen: A series of luminescent monometallic fac-[Re(bipy)(CO)3(L)]+ and heterometallic fac-[Re(bipy)(CO)3(L-AuPPh3)]+ complexes, where L is an imidazole, alkynyl-imidazole or alkynyl-pyridine derivative, have been synthesised for the purpose of finding a synergic effect between the excellent photophysical properties of rhenium complexes and the good antiproliferative effects of gold compounds. Cytotoxicity studies performed in human A549 lung cancer cells revealed the importance of the alkynyl–phosphine–gold fragment within the probe to design efficient anticancer agents. Heterometallic Re(I)/Au(I) derivatives presented values of IC50 more than 10 times lower than their analogous Re(I) complexes. In addition, fluorescent cell microscopy pointed out the different biodistribution behaviour of the monometallic and heterometallic families. Whereas the monometallic Re(I) species showed some general cytoplasmatic staining with mitochondrial accumulation, the heterometallic Re(I)/Au(I) derivatives shifted from localising in the mitochondria to the nucleus and nucleolus upon increasing the loading concentration, suggesting a completely different driving force for their localisation pattern. These facts revealed that these bimetallic species can be excellent partners in cell imaging and cancer therapy.

Idioma: Inglés

DOI: 10.1039/c4sc01684j

Año: 2014

Publicado en: CHEMICAL SCIENCE 5, 11 (2014), 4434-4446
ISSN: 2041-6520

Factor impacto JCR: 9.211 (2014)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 14 / 154 = 0.091 (2014) - Q1 - T1

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/B16
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E77
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2010-20500-C02-0
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/SAF2010-14920

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
Área (Departamento): Proy. investigación HWA (Dpto. Química Inorgánica)
Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)