Luminescent Re(i) and Re(i)/Au(i) complexes as cooperative partners in cell imaging and cancer therapy
Fernández-Moreira, Vanesa (Universidad de Zaragoza) ; Marzo, Isabel (Universidad de Zaragoza) ; Gimeno, M. Concepción (Universidad de Zaragoza)
Resumen: A series of luminescent monometallic fac-[Re(bipy)(CO)3(L)]+ and heterometallic fac-[Re(bipy)(CO)3(L-AuPPh3)]+ complexes, where L is an imidazole, alkynyl-imidazole or alkynyl-pyridine derivative, have been synthesised for the purpose of finding a synergic effect between the excellent photophysical properties of rhenium complexes and the good antiproliferative effects of gold compounds. Cytotoxicity studies performed in human A549 lung cancer cells revealed the importance of the alkynyl–phosphine–gold fragment within the probe to design efficient anticancer agents. Heterometallic Re(I)/Au(I) derivatives presented values of IC50 more than 10 times lower than their analogous Re(I) complexes. In addition, fluorescent cell microscopy pointed out the different biodistribution behaviour of the monometallic and heterometallic families. Whereas the monometallic Re(I) species showed some general cytoplasmatic staining with mitochondrial accumulation, the heterometallic Re(I)/Au(I) derivatives shifted from localising in the mitochondria to the nucleus and nucleolus upon increasing the loading concentration, suggesting a completely different driving force for their localisation pattern. These facts revealed that these bimetallic species can be excellent partners in cell imaging and cancer therapy.
Idioma: Inglés
DOI: 10.1039/c4sc01684j
Año: 2014
Publicado en: CHEMICAL SCIENCE 5, 11 (2014), 4434-4446
ISSN: 2041-6520
Factor impacto JCR: 9.211 (2014)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 14 / 154 = 0.091 (2014) - Q1 - T1
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/B16
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E77
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2010-20500-C02-0
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/SAF2010-14920
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
Área (Departamento): Proy. investigación HWA (Dpto. Química Inorgánica)
Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.1039/c4sc01684j
Año: 2014
Publicado en: CHEMICAL SCIENCE 5, 11 (2014), 4434-4446
ISSN: 2041-6520
Factor impacto JCR: 9.211 (2014)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 14 / 154 = 0.091 (2014) - Q1 - T1
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/B16
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E77
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2010-20500-C02-0
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/SAF2010-14920
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)
Área (Departamento): Proy. investigación HWA (Dpto. Química Inorgánica)
Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2025-01-16-14:31:25)
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Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Química Inorgánica
Articles > Artículos por área > biologia_celular
Record created 2025-01-16, last modified 2025-01-16