Absorbable stents for treatment of benign biliary strictures: long-term follow-up in the prospective Spanish registry

Gregorio , Miguel Ángel de (Universidad de Zaragoza) ; Criado, Eva ; Guirola, Jose A (Universidad de Zaragoza) ; Alvarez-Arranz, Enrique ; Pérez-Lafuente, Mercedes ; Barrufet, Marta ; Ferrer-Puchol, María de ; López-Mínguez, Sandra (Universidad de Zaragoza) ; Urbano, José ; Lanciego, Carlos ; Aguinaga, Alexander ; Capel, Antonio ; Ponce-Dorrego, María de ; Gregorio, Abel ; Spanish group BiELLA (SERVEI)

Resumen: Objectives Benign strictures of the bile duct may be difficult to treat endoscopically due to altered bowel anatomy. Furthermore, recurrence of stenosis and symptoms remains high. The aim of the Spanish Prospective Registry BiELLA study was to investigate the safety and efficacy of absorbable stents in the treatment of benign biliary strictures and their outcomes on the medium and long-term follow-up.
Methods A prospective, multicenter, observational, non-randomized study (the BiELLA study) was conducted from January
2014 to September 2018. One hundred fifty-nine patients with benign biliary strictures, mostly postsurgical, were enrolled for implantation of absorbable biliary stents in the 11 participating Spanish tertiary hospitals. The average patient follow-up was 45.4 ± 15.9months (range, 12–60 months). The follow-up data included symptoms, biochemical parameters, and ultrasound images at 1, 6, and 12 months and then yearly for up to 60 months.
Results The immediate technical and clinical success rates were 100%. In all patients, stent placement resulted in improvement of clinical symptoms and biochemical parameters. The primary mean patency for stent was 86.7, 79.6, and 78.9% at 12, 36, and 60 months, respectively (95%CI). Biliary restenosis and occlusion occurred in 40 (26.6%) patients. Of the 40 patients, 18 (12%) patients were treated with a second stent and 22 (14.6%) patients had operative repair of the recurrent strictures. There were no major complications associated with stent implantation.
Conclusions Implantation of an absorbable polydioxanone biliary stent is safe and effective for treatment of benign biliary strictures refractory to balloon dilatation or other biliary intervention.

Idioma: Inglés

DOI: 10.1007/s00330-020-06797-7

Año: 2020

Publicado en: European radiology 30 (2020), 4486–4495
ISSN: 0938-7994

Factor impacto JCR: 5.315 (2020)

Categ. JCR: RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING rank: 22 / 133 = 0.165 (2020) - Q1 - T1

Factor impacto SCIMAGO: 1.606 - Radiology, Nuclear Medicine and Imaging (Q1) - Medicine (miscellaneous) (Q1)

Tipo y forma: Article (Published version)

Área (Departamento): Área Radiol. y Medicina Física (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)