Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat
Fuentes-Broto, Lorena (Universidad de Zaragoza) ; Perdices, Lorena ; Segura, Francisco (Universidad de Zaragoza) ; Cavero, Ana ; Orduna-Hospital, Elvira ; Insa-Sánchez, Gema (Universidad de Zaragoza) ; Sánchez-Cano, AnaIsabel (Universidad de Zaragoza) ; Fernández-Sánchez, Laura ; Cuenca, Nicolás ; Pinilla, Isabel (Universidad de Zaragoza)
Resumen: Retinitis pigmentosa (RP) is a group of inherited retinal disorders that lead to photoreceptor loss. RP has been reported to be related to oxidative stress, autophagy, and inflammation. (-)-Epigallocatechin gallate (EGCG), the most abundant catechin-based flavonoid in green tea leaves, has significant antioxidant, anti-carcinogenic, antimicrobial, and neuroprotective properties. EGCG, given its low molecular weight and hydrophilic properties, can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens, cornea, and retina. EGCG has been shown to provide retinal protection against ischemia; sodium nitroprusside-, N-methyl-D-aspartate-, lipopolysaccharide-, light-, sodium iodate-, or H2O2-induced damage and diabetic retinopathy. This suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as RP. The aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23H line 1, the model of RP. Albino P23H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of RP. Pigmented P23H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans rats. Rats treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23H rats treated with vehicle. EGCG reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase activities. No differences were observed in visual acuity, nitrate levels, nitrite levels or glutathione S-transferase activity. In conclusion, EGCG not only reduced the loss of visual function in P23H rats but also improved the levels of antioxidant enzymes and reduced oxidative damage. This study was approved by the Institutional Animal Care and Use Committee (CEICA) from the University of Zaragoza under project license PI12/14 on July 11, 2014.
Idioma: Inglés
DOI: 10.4103/1673-5374.320990
Año: 2022
Publicado en: NEURAL REGENERATION RESEARCH 17, 3 (2022), 625
ISSN: 1673-5374
Factor impacto JCR: 6.1 (2022)
Categ. JCR: NEUROSCIENCES rank: 42 / 272 = 0.154 (2022) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 58 / 191 = 0.304 (2022) - Q2 - T1
Factor impacto CITESCORE: 7.4 - Neuroscience (Q1)
Factor impacto SCIMAGO: 0.837 - Developmental Neuroscience (Q2)
Tipo y forma: Article (Published version)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
Exportado de SIDERAL (2025-01-26-10:47:37)
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Idioma: Inglés
DOI: 10.4103/1673-5374.320990
Año: 2022
Publicado en: NEURAL REGENERATION RESEARCH 17, 3 (2022), 625
ISSN: 1673-5374
Factor impacto JCR: 6.1 (2022)
Categ. JCR: NEUROSCIENCES rank: 42 / 272 = 0.154 (2022) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 58 / 191 = 0.304 (2022) - Q2 - T1
Factor impacto CITESCORE: 7.4 - Neuroscience (Q1)
Factor impacto SCIMAGO: 0.837 - Developmental Neuroscience (Q2)
Tipo y forma: Article (Published version)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. Exportado de SIDERAL (2025-01-26-10:47:37)
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Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Oftalmología
Articles > Artículos por área > Fisiología
Articles > Artículos por área > Optica
Record created 2025-01-26, last modified 2025-01-26