Systematic review and meta-analysis of Spanish studies regarding the association between maternal 25-hydroxyvitamin D levels and perinatal outcomes

Martínez-Domínguez, S.J. ; Tajada, M. (Universidad de Zaragoza) ; Chedraui, P. ; Pérez-López, F.R. (Universidad de Zaragoza)

Resumen: Objective: This systematic review and meta-analysis of Spanish studies assessed the association of maternal 25-hydroxyvitamin D [25(OH)D] levels on perinatal outcomes. Methods: PubMed, Cochrane Library, Embase, Scielo, Scopus, and Web of Science research databases were searched from inception through December 30 2017 using the terms ‘vitamin D’, ‘pregnancy’, and ‘Spain’. Studies that compared first or second half of pregnancy normal 25(OH)D (=30.0 ng/mL) versus insufficient (20.0–29.9 ng/mL) or deficient (<20.0 ng/mL) circulating levels and perinatal outcomes were systematically extracted. Data are presented as pooled odds ratios and their 95% confidence intervals (CIs) for categorical variables or mean differences and CIs for continuous variables. Risk of bias was evaluated with the Newcastle–Ottawa Scale. Results: Five cohort studies met inclusion criteria. The risk of gestational diabetes mellitus, preeclampsia, preterm birth, and small-for-gestational-age infants, and birthweight was not influenced by first half of pregnancy maternal 25(OH)D levels. In addition, second half of pregnancy 25(OH) levels did not affect birthweight. Conclusion: Maternal 25(OH)D levels during pregnancy did not affect studied perinatal outcomes and birthweight.

Idioma: Inglés

DOI: 10.1080/09513590.2018.1472761

Año: 2018

Publicado en: GYNECOLOGICAL ENDOCRINOLOGY 34, 11 (2018), 987-994
ISSN: 0951-3590

Factor impacto JCR: 1.406 (2018)

Categ. JCR: OBSTETRICS & GYNECOLOGY rank: 63 / 82 = 0.768 (2018) - Q4 - T3
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 129 / 145 = 0.89 (2018) - Q4 - T3

Factor impacto SCIMAGO: 0.599 - Endocrinology (Q2) - Obstetrics and Gynecology (Q2) - Endocrinology, Diabetes and Metabolism (Q2)

Tipo y forma: Article (Published version)

Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía,Ginecol.Obstetr.)