Effects of the relationship between 65Zn and blood cells. A dynamic and morphological study

Vera-Gil, A. (Universidad de Zaragoza) ; Pérez Castejón, M.J. ; Whyte, J. (Universidad de Zaragoza) ; Cisneros, A. (Universidad de Zaragoza) ; Recreo, P. (Universidad de Zaragoza) ; Gascón, M.A. ; Whyte, A. (Universidad de Zaragoza) ; Lahoz, M. ; Pérez Castejón, M.C. (Universidad de Zaragoza)

Resumen: We have studied the dynamic pathway of Zn and its autoradiographic location in blood cells, even at the ultra-structural level. We have found evidence that tends to confirm the old biochemical postulates about the capacity of this isotope to displace iron in the haemoglobin molecule. Recently, the bibliography has demonstrated that ⁵⁷Co is also able to perform this displacement, but unlike Zn it does not invalidate the Redox function of the molecule. In the case of Zn, the mentioned displacement invalidates this function because the radionuclide can only use valence 2. We have also contributed evidence of erythrocytes destruction by the spleen after the incorporation of Zn, as well as the clearly marked degradation of haematic pigments inside the spleen.

Idioma: Inglés

DOI: 10.14670/HH-28.1007

Año: 2013

Publicado en: Histology and histopathology 28, 8 (2013), 1007-1011
ISSN: 0213-3911

Factor impacto JCR: 2.236 (2013)

Categ. JCR: PATHOLOGY rank: 34 / 76 = 0.447 (2013) - Q2 - T2
Categ. JCR: CELL BIOLOGY rank: 131 / 184 = 0.712 (2013) - Q3 - T3

Tipo y forma: Article (Published version)

Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Area Anatom.Embriol.Humana (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)