000150256 001__ 150256
000150256 005__ 20250203110525.0
000150256 0247_ $$2doi$$a10.1007/s10237-011-0369-0
000150256 0248_ $$2sideral$$a78924
000150256 037__ $$aART-2012-78924
000150256 041__ $$aeng
000150256 100__ $$0(orcid)0000-0002-8503-9291$$aCilla, M.$$uUniversidad de Zaragoza
000150256 245__ $$a3D computational parametric analysis of eccentric atheroma plaque: Influence of axial and circumferential residual stresses
000150256 260__ $$c2012
000150256 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150256 5203_ $$aPlaque rupture plays a role in the majority of acute coronary syndromes. Rupture has usually been associated with stress concentrations, which are mainly affected by the plaque geometry and the tissue properties. The aim of this study is to evaluate the influence of morphology on the risk of plaque rupture, including the main geometrical factors, and to assess the role of circumferential and axial residual stresses by means of a parametric 3D finite element model. For this purpose, a 3D parametric finite element model of the coronary artery with eccentric atheroma plaque was developed. Healthy (adventitia and media in areas without atheroma plaque) and diseased (fibrotic and lipidic) tissues were considered in the model. The geometrical parameters used to define and design the idealized coronary plaque anatomy were the lipid core length, the stenosis ratio, the fibrous cap thickness, and the lipid core ratio. Finally, residual stresses in longitudinal and circumferential directions were incorporated into the model to analyse the influence of the important mechanical factors in the vulnerability of the plaque. Viewing the results, we conclude that residual stresses should be considered in the modelling of this kind of problems since they cause a significant alteration of the vulnerable plaque region limits. The obtained results show that the fibrous cap thickness and the lipid core length, in combination with the lipid core width, appear to be the key morphological parameters that play a determinant role in the maximal principal stress (MPS). However, the stenosis ratio is found to not play a significant role in vulnerability related to the MPS. Plaque rupture should therefore be observed as a consequence, not only of the cap thickness, but as a combination of the stenosis ratio, the fibrous cap thickness and the lipid core dimensions.
000150256 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B137-09$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2010-20746-C03-01
000150256 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000150256 590__ $$a3.331$$b2012
000150256 591__ $$aENGINEERING, BIOMEDICAL$$b11 / 76 = 0.145$$c2012$$dQ1$$eT1
000150256 591__ $$aBIOPHYSICS$$b26 / 71 = 0.366$$c2012$$dQ2$$eT2
000150256 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000150256 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, E.$$uUniversidad de Zaragoza
000150256 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, M. A.$$uUniversidad de Zaragoza
000150256 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000150256 773__ $$g11, 7 (2012), 1001-1013$$pBiomech. model. mechanobiol.$$tBIOMECHANICS AND MODELING IN MECHANOBIOLOGY$$x1617-7959
000150256 8564_ $$s9446367$$uhttps://zaguan.unizar.es/record/150256/files/texto_completo.pdf$$yPostprint
000150256 8564_ $$s2684828$$uhttps://zaguan.unizar.es/record/150256/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000150256 909CO $$ooai:zaguan.unizar.es:150256$$particulos$$pdriver
000150256 951__ $$a2025-02-03-11:02:16
000150256 980__ $$aARTICLE