Effect of Transmural Transport Properties on Atheroma Plaque Formation and Development

Cilla, M. ; Martínez, M. A. (Universidad de Zaragoza) ; Peña, E. (Universidad de Zaragoza)

Resumen: We propose a mathematical model of atheroma plaque initiation and early development in coronary arteries using anisotropic transmural diffusion properties. Our current approach is on the process on plaque initiation and intimal thickening rather than in severe plaque progression and rupture phenomena. The effect of transport properties, in particular the anisotropy of diffusion properties of the artery, on plaque formation and development is investigated using the proposed mathematical model. There is not a strong influence of the anisotropic transmural properties on LDL, SMCs and collagen distribution and concentrations along the artery. On the contrary, foam cells distribution strongly depends on the value of the radial diffusion coefficient of the substances and the ratio . Decreasing or diffusion coefficients ratio means a higher concentration of the foam cells close to the intima. Due to the fact that foam cells concentration is associated to the necrotic core formation, the final distribution of foam cells is critical to evolve into a vulnerable or fibrotic plaque.

Idioma: Inglés

DOI: 10.1007/s10439-015-1299-2

Año: 2015

Publicado en: Annals of Biomedical Engineering 43, 7 (2015), 1516-1530
ISSN: 0090-6964

Factor impacto JCR: 2.887 (2015)

Categ. JCR: ENGINEERING, BIOMEDICAL rank: 16 / 76 = 0.211 (2015) - Q1 - T1

Factor impacto SCIMAGO: 1.2 - Biomedical Engineering (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)