Independent effect of body fat content on inflammatory biomarkers in children and adolescents: The GENOBOX study

Skapino, Estela ; Gonzalez-Gayan, Laura ; Seral-Cortes, Miguel (Universidad de Zaragoza) ; Sabroso-Lasa, Sergio ; Llorente-Cereza, Ma Teresa (Universidad de Zaragoza) ; Leis, Rosaura ; Aguilera, Concepción M. ; Gil-Campos, Mercedes ; Moreno, Luis A. (Universidad de Zaragoza) ; Bueno-Lozano, Gloria (Universidad de Zaragoza)

Resumen: Background and aims: To assess the relationship between body composition indicators and inflammatory bio-markers in children and adolescents of the GENOBOX study.
Methods and results: Anthropometry data from 264 subjects from the subsample of Zaragoza (Spain) included: weight, height, waist circumference, body mass index and triponderal index. Body composition was determined by Dual-energy X-ray Absorptiometry (DXA), obtaining visceral adipose tissue, fat mass index and lean mass index. Age and sex specific z-scores were computed. Simple linear regression models were performed with in-flammatory biomarkers (hsCRP, IL8, TNF-α, adiponectin, leptin and resistin) as dependent variables, and each of the body composition indices as independent variables.
Prepubertal boys had higher IL8 and resistin values and pubertal girls had higher HOMA-IR and leptin values. hsCPR and leptin were associated with fat mass, both in prepubertals and pubertals, independently of lean mass, and regardless of how body composition was measured. All body composition indices were inversely associated with adiponectin, except for fat mass index in pubertals, but none of them were statistically significant. Conclusion: A positive association between hsCRP and leptin with all body fat composition parameters, measured by standard nutritional indicators and DXA, was observed in both sexual stages.

Idioma: Inglés

DOI: 10.1016/j.numecd.2024.103811

Año: 2024

Publicado en: Nutrition, Metabolism and Cardiovascular Diseases 35, 4 (2024), 103811 [8 pp.]
ISSN: 0939-4753

Factor impacto JCR: 3.7 (2024)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 55 / 230 = 0.239 (2024) - Q1 - T1
Categ. JCR: NUTRITION & DIETETICS rank: 39 / 112 = 0.348 (2024) - Q2 - T2
Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 63 / 191 = 0.33 (2024) - Q2 - T1

Factor impacto SCIMAGO: 1.098 - Cardiology and Cardiovascular Medicine (Q1) - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1) - Endocrinology, Diabetes and Metabolism (Q2)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI051968
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU16-03653
Financiación: info:eu-repo/grantAgreement/ES/MICIN-ISCIII/IFI17-00048

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Pediatría (Dpto. Microb.Ped.Radio.Sal.Pú.)