000150577 001__ 150577
000150577 005__ 20251017144652.0
000150577 0247_ $$2doi$$a10.46389/rjd-2024-1441
000150577 0248_ $$2sideral$$a142658
000150577 037__ $$aART-2024-142658
000150577 041__ $$aeng
000150577 100__ $$aAllaoui, Amine
000150577 245__ $$aPostprandial changes in gene expression of hepatic cholesterol metabolism in response to two protein sources in the rat
000150577 260__ $$c2024
000150577 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150577 5203_ $$aA hypocholesterolemic effect of chickpea (CPH) and sardine protein hydrolysates (SPH) has been observed. Two main mechanisms could be involved in explaining this fact: the inhibition of cholesterol enterohepatic cycle and a post-absorptive regulatory pathway. We aimed to check whether these hypotheses were involved in the present study. Three groups of rats were given a single dose of a cholesterol-oil solution (HC), supplemented or not with CPH or SPH. The postprandial transcription levels of some genes involved in cholesterol metabolism were assessed in their livers. Four hours after feeding, the results showed that Mttp, Pltp, Cidec, Abca1, and Abcg1 gene expressions were similar among the different groups. Lcat mRNA was 5.5-fold higher in CPH and SPH rats’ liver vs. HC, but this difference was not statistically significant. SPH tends to upregulate Ldlr expression, while CPH tends to upregulate Cyp7a1 transcription (2- and 8-fold, respectively, compared to HC rats, p=0.083 according to the Mann-Whitney test). Pon1 and Apoa1 were not affected by the hydrolysate supplementation vs. HC group. In conclusion, these results suggest that chickpeas and sardine protein hydrolysates exert hypocholesterolemic activity mainly by enterohepatic inhibiting the cholesterol cycle rather than modulating the postprandial gene expressions involved in cholesterol metabolism.
000150577 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000150577 592__ $$a0.139$$b2024
000150577 593__ $$aInternal Medicine$$c2024$$dQ4
000150577 593__ $$aEndocrinology, Diabetes and Metabolism$$c2024$$dQ4
000150577 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150577 700__ $$aDehiba, Faiza
000150577 700__ $$0(orcid)0000-0002-4665-9674$$aHerrera Marcos, Luis Vicente$$uUniversidad de Zaragoza
000150577 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez Yoldi, María Jesús$$uUniversidad de Zaragoza
000150577 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000150577 700__ $$aBoualga, Ahmed
000150577 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000150577 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000150577 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000150577 773__ $$g31, 2 (2024), 143-149$$tRomanian Journal of Diabetes, Nutrition and Metabolic Diseases$$x1583-8609
000150577 8564_ $$s764440$$uhttps://zaguan.unizar.es/record/150577/files/texto_completo.pdf$$yVersión publicada
000150577 8564_ $$s2685191$$uhttps://zaguan.unizar.es/record/150577/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150577 909CO $$ooai:zaguan.unizar.es:150577$$particulos$$pdriver
000150577 951__ $$a2025-10-17-14:36:43
000150577 980__ $$aARTICLE