000150651 001__ 150651
000150651 005__ 20251017144626.0
000150651 0247_ $$2doi$$a10.1039/d2cs00518b
000150651 0248_ $$2sideral$$a129479
000150651 037__ $$aART-2022-129479
000150651 041__ $$aeng
000150651 100__ $$0(orcid)0000-0003-4874-6672$$aGarcia-Peiro, Jose Ignacio$$uUniversidad de Zaragoza
000150651 245__ $$aPlatinum Nanoplatforms: Classic Catalysts Claiming a Prominent Role in Cancer Therapy
000150651 260__ $$c2022
000150651 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150651 5203_ $$aPlatinum nanoparticles (Pt NPs) have a well-established role as a classic heterogeneous catalyst. Also, Pt has traditionally been employed as a component of organometallic drug formulations for chemotherapy. However, a new role in cancer therapy is emerging thanks to its outstanding catalytic properties, enabling novel approaches that are surveyed in this review. Herein, we critically discuss results already obtained and attempt to ascertain future perspectives for Pt NPs as catalysts able to modify key processes taking place in the tumour microenvironment (TME). In addition, we explore relevant parameters affecting the cytotoxicity, biodistribution and clearance of Pt systems. We also analyze pros and cons in terms of biocompatibility and potential synergies that emerge from combining the catalytic capabilities of Pt with other agents such as co-catalysts, external energy sources (near-infrared light, X-ray, electric currents) and conventional therapies.
000150651 536__ $$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE
000150651 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000150651 590__ $$a46.2$$b2022
000150651 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b2 / 178 = 0.011$$c2022$$dQ1$$eT1
000150651 592__ $$a15.109$$b2022
000150651 593__ $$aChemistry (miscellaneous)$$c2022$$dQ1
000150651 594__ $$a81.3$$b2022
000150651 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000150651 700__ $$0(orcid)0000-0002-1791-0188$$aBonet-Aleta, Javier$$uUniversidad de Zaragoza
000150651 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, Jesús$$uUniversidad de Zaragoza
000150651 700__ $$0(orcid)0000-0002-4546-4111$$aHueso Martos, José Luis$$uUniversidad de Zaragoza
000150651 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000150651 773__ $$g51, 17 (2022), 7662-7681$$pChem. Soc. rev.$$tChemical Society Reviews$$x0306-0012
000150651 8564_ $$s1836928$$uhttps://zaguan.unizar.es/record/150651/files/texto_completo.pdf$$yPostprint
000150651 8564_ $$s2217933$$uhttps://zaguan.unizar.es/record/150651/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000150651 909CO $$ooai:zaguan.unizar.es:150651$$particulos$$pdriver
000150651 951__ $$a2025-10-17-14:24:13
000150651 980__ $$aARTICLE