Platinum Nanoplatforms: Classic Catalysts Claiming a Prominent Role in Cancer Therapy

Garcia-Peiro, Jose Ignacio (Universidad de Zaragoza) ; Bonet-Aleta, Javier (Universidad de Zaragoza) ; Santamaría, Jesús (Universidad de Zaragoza) ; Hueso Martos, José Luis (Universidad de Zaragoza)

Resumen: Platinum nanoparticles (Pt NPs) have a well-established role as a classic heterogeneous catalyst. Also, Pt has traditionally been employed as a component of organometallic drug formulations for chemotherapy. However, a new role in cancer therapy is emerging thanks to its outstanding catalytic properties, enabling novel approaches that are surveyed in this review. Herein, we critically discuss results already obtained and attempt to ascertain future perspectives for Pt NPs as catalysts able to modify key processes taking place in the tumour microenvironment (TME). In addition, we explore relevant parameters affecting the cytotoxicity, biodistribution and clearance of Pt systems. We also analyze pros and cons in terms of biocompatibility and potential synergies that emerge from combining the catalytic capabilities of Pt with other agents such as co-catalysts, external energy sources (near-infrared light, X-ray, electric currents) and conventional therapies.

Idioma: Inglés

DOI: 10.1039/d2cs00518b

Año: 2022

Publicado en: Chemical Society Reviews 51, 17 (2022), 7662-7681
ISSN: 0306-0012

Factor impacto JCR: 46.2 (2022)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 2 / 178 = 0.011 (2022) - Q1 - T1

Factor impacto CITESCORE: 81.3 - Chemistry (Q1)

Factor impacto SCIMAGO: 15.109 - Chemistry (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)