Quantification of the anterior–centripetal movement of the ciliary muscle during accommodation using dynamic OCT imaging
Cabeza-Gil, Iulen ; Ruggeri, Marco ; Manns, Fabrice
Resumen: Purpose:
Although the lens undoubtedly plays a major role in presbyopia, altered lens function could be in part secondary to age-related changes of the ciliary muscle. Ciliary muscle changes with accommodation have been quantified using optical coherence tomography, but so far these studies have been limited to quantifying changes in ciliary muscle thickness, mostly at static accommodative states. Quantifying ciliary muscle thickness changes does not effectively capture the dynamic anterior centripetal movement of the ciliary muscle during accommodation. To address this issue, we present a method to quantify the movement of the ciliary muscle during accommodation using trans-scleral optical coherence tomography images obtained dynamically.
Methods:
An image processing framework including distortion correction, geometric transformation, and Procrustes analysis, was used to quantify the anterior–centripetal movement of the ciliary muscle apex and centroid during accommodation. The method was applied in a preliminary study to quantify ciliary muscle displacement and its relation to lens thickness change with accommodation on two young adults and two prepresbyopes.
Results:
The magnitude and the direction relative to the pupil plane of the apex/centroid displacement in response to a two diopters (2D) stimulus were 0.16/0.20 mm at 11.3°/30.5° and 0.26/0.34 mm at 6.6°/33.2° for the young adults and 0.20/0.20 mm at 29.7°/40.6° and 0.24/0.40 mm at 33.0°/31.7° for the prepresbyopes, respectively.
Conclusions:
This study demonstrates the feasibility of quantifying dynamic anterior– centripetal movement of the ciliary muscle during accommodation using optical coherence tomography. The method better captures the functional response of the muscle
than the quantification of thickness changes.
Translational Relevance:
We provide a method that holds potential to better understand the age-related changes of the ciliary muscle on presbyopia.
Idioma: Inglés
DOI: 10.1167/tvst.14.1.17
Año: 2025
Publicado en: Translational Vision Science and Technology 14, 17 (2025), 11
ISSN: 2164-2591
Tipo y forma: Artículo (Versión definitiva)
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Although the lens undoubtedly plays a major role in presbyopia, altered lens function could be in part secondary to age-related changes of the ciliary muscle. Ciliary muscle changes with accommodation have been quantified using optical coherence tomography, but so far these studies have been limited to quantifying changes in ciliary muscle thickness, mostly at static accommodative states. Quantifying ciliary muscle thickness changes does not effectively capture the dynamic anterior centripetal movement of the ciliary muscle during accommodation. To address this issue, we present a method to quantify the movement of the ciliary muscle during accommodation using trans-scleral optical coherence tomography images obtained dynamically.
Methods:
An image processing framework including distortion correction, geometric transformation, and Procrustes analysis, was used to quantify the anterior–centripetal movement of the ciliary muscle apex and centroid during accommodation. The method was applied in a preliminary study to quantify ciliary muscle displacement and its relation to lens thickness change with accommodation on two young adults and two prepresbyopes.
Results:
The magnitude and the direction relative to the pupil plane of the apex/centroid displacement in response to a two diopters (2D) stimulus were 0.16/0.20 mm at 11.3°/30.5° and 0.26/0.34 mm at 6.6°/33.2° for the young adults and 0.20/0.20 mm at 29.7°/40.6° and 0.24/0.40 mm at 33.0°/31.7° for the prepresbyopes, respectively.
Conclusions:
This study demonstrates the feasibility of quantifying dynamic anterior– centripetal movement of the ciliary muscle during accommodation using optical coherence tomography. The method better captures the functional response of the muscle
than the quantification of thickness changes.
Translational Relevance:
We provide a method that holds potential to better understand the age-related changes of the ciliary muscle on presbyopia.
Idioma: Inglés
DOI: 10.1167/tvst.14.1.17
Año: 2025
Publicado en: Translational Vision Science and Technology 14, 17 (2025), 11
ISSN: 2164-2591
Tipo y forma: Artículo (Versión definitiva)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.Exportado de SIDERAL (2025-02-14-14:04:15)
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Registro creado el 2025-02-14, última modificación el 2025-02-14