000150762 001__ 150762
000150762 005__ 20250214153851.0
000150762 0247_ $$2doi$$a10.1167/tvst.14.1.17
000150762 0248_ $$2sideral$$a142862
000150762 037__ $$aART-2025-142862
000150762 041__ $$aeng
000150762 100__ $$0(orcid)0000-0001-8219-2365$$aCabeza-Gil, Iulen
000150762 245__ $$aQuantification of the anterior–centripetal movement of the ciliary muscle during accommodation using dynamic OCT imaging
000150762 260__ $$c2025
000150762 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150762 5203_ $$aPurpose:
Although the lens undoubtedly plays a major role in presbyopia, altered lens function could be in part secondary to age-related changes of the ciliary muscle. Ciliary muscle changes with accommodation have been quantified using optical coherence tomography, but so far these studies have been limited to quantifying changes in ciliary muscle thickness, mostly at static accommodative states. Quantifying ciliary muscle thickness changes does not effectively capture the dynamic anterior centripetal movement of the ciliary muscle during accommodation. To address this issue, we present a method to quantify the movement of the ciliary muscle during accommodation using trans-scleral optical coherence tomography images obtained dynamically.
Methods:
An image processing framework including distortion correction, geometric transformation, and Procrustes analysis, was used to quantify the anterior–centripetal movement of the ciliary muscle apex and centroid during accommodation. The method was applied in a preliminary study to quantify ciliary muscle displacement and its relation to lens thickness change with accommodation on two young adults and two prepresbyopes.
Results:
The magnitude and the direction relative to the pupil plane of the apex/centroid displacement in response to a two diopters (2D) stimulus were 0.16/0.20 mm at 11.3°/30.5° and 0.26/0.34 mm at 6.6°/33.2° for the young adults and 0.20/0.20 mm at 29.7°/40.6° and 0.24/0.40 mm at 33.0°/31.7° for the prepresbyopes, respectively.
Conclusions:
This study demonstrates the feasibility of quantifying dynamic anterior– centripetal movement of the ciliary muscle during accommodation using optical coherence tomography. The method better captures the functional response of the muscle
than the quantification of thickness changes.
Translational Relevance:
We provide a method that holds potential to better understand the age-related changes of the ciliary muscle on presbyopia.
000150762 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000150762 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150762 700__ $$aRuggeri, Marco
000150762 700__ $$aManns, Fabrice
000150762 773__ $$g14, 17 (2025), 11$$pTransl. vis. sci. technol.$$tTranslational Vision Science and Technology$$x2164-2591
000150762 8564_ $$s1146152$$uhttps://zaguan.unizar.es/record/150762/files/texto_completo.pdf$$yVersión publicada
000150762 8564_ $$s2801273$$uhttps://zaguan.unizar.es/record/150762/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150762 909CO $$ooai:zaguan.unizar.es:150762$$particulos$$pdriver
000150762 951__ $$a2025-02-14-14:04:15
000150762 980__ $$aARTICLE