Lessons to Learn from the Gut Microbiota: A Focus on Amyotrophic Lateral Sclerosis

Calvo, Ana Cristina (Universidad de Zaragoza) ; Valledor-Martín, Inés ; Moreno-Martínez, Laura (Universidad de Zaragoza) ; Toivonen, Janne Markus (Universidad de Zaragoza) ; Osta, Rosario (Universidad de Zaragoza)

Resumen: The gut microbiota is able to modulate the development and homeostasis of the central nervous system (CNS) through the immune, circulatory, and neuronal systems. In turn, the CNS influences the gut microbiota through stress responses and at the level of the endocrine system. This bidirectional communication forms the “gut microbiota–brain axis” and has been postulated to play a role in the etiopathology of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Numerous studies in animal models of ALS and in patients have highlighted the close communication between the immune system and the gut microbiota and, therefore, it is possible that alterations in the gut microbiota may have a direct impact on neuronal function and survival in ALS patients. Consequently, if the gut dysbiosis does indeed play a role in ALS-related neurodegeneration, nutritional immunomodulatory interventions based on probiotics, prebiotics, and/or postbiotics could emerge as innovative therapeutic strategies. This review aimed to shed light on the impact of the gut microbiota in ALS disease and on the use of potential nutritional interventions based on different types of biotics to ameliorate ALS symptoms.

Idioma: Inglés

DOI: 10.3390/genes13050865

Año: 2022

Publicado en: Genes 13, 5 (2022), 865 [13 pp.]
ISSN: 2073-4425

Factor impacto JCR: 3.5 (2022)

Categ. JCR: GENETICS & HEREDITY rank: 66 / 171 = 0.386 (2022) - Q2 - T2

Factor impacto CITESCORE: 5.1 - Medicine (Q2) - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 0.924 - Genetics (clinical) (Q2) - Genetics (Q2)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FEDER/PI21-00372

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Farmacología (Dpto. Farmac.Fisiol.y Med.L.F.)