000151122 001__ 151122
000151122 005__ 20250227101503.0
000151122 0247_ $$2doi$$a10.1016/j.ijpharm.2021.120454
000151122 0248_ $$2sideral$$a125748
000151122 037__ $$aART-2021-125748
000151122 041__ $$aeng
000151122 100__ $$aZiani, K.
000151122 245__ $$aCharacterization of encapsulated porcine cardiosphere-derived cells embedded in 3D alginate matrices
000151122 260__ $$c2021
000151122 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151122 5203_ $$aMyocardial infarction is caused by an interruption of coronary blood flow, leading to one of the main death causes worldwide. Current therapeutic approaches are palliative and not able to solve the loss of cardiac tissue. Cardiosphere derived cells (CDCs) reduce scarring, and increase viable myocardium, with safety and adequate biodistribution, but show a low rate engraftment and survival after implantation. In order to solve the low retention, we propose the encapsulation of CDCs within three-dimensional alginate-poly-L-lysine-alginate matrix as therapy for cardiac regeneration. In this work, we demonstrate the encapsulation of CDCs in alginate matrix, with no decrease in viability over a month, and showing the preservation of CDCs phenotype, differentiation potential, gene expression profile and growth factor release after encapsulation, moving a step forward to clinical translation of CDCs therapy in regeneration in heart failure.
000151122 536__ $$9info:eu-repo/grantAgreement/EC/H2020/78132/EU/Electronic Components and Systems for European Leadership Joint Undertaking/ECSEL JU-78132-Position-II-2017-IA$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 78132-ECSEL JU-78132-Position-II-2017-IA
000151122 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000151122 590__ $$a6.51$$b2021
000151122 591__ $$aPHARMACOLOGY & PHARMACY$$b40 / 279 = 0.143$$c2021$$dQ1$$eT1
000151122 592__ $$a1.0$$b2021
000151122 593__ $$aPharmaceutical Science$$c2021$$dQ1
000151122 594__ $$a9.6$$b2021
000151122 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151122 700__ $$aEspona-Noguera, A.
000151122 700__ $$aCrisostomo, V.
000151122 700__ $$aCasado, J.G.
000151122 700__ $$aSanchez-Margallo, F.M.
000151122 700__ $$aSaenz-del-Burgo, L.
000151122 700__ $$0(orcid)0000-0002-8666-622X$$aCiriza, J.$$uUniversidad de Zaragoza
000151122 700__ $$aPedraz, J.L.
000151122 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000151122 773__ $$g599 (2021), [11 pp.]$$pInt. j. pharm.$$tInternational Journal of Pharmaceutics$$x0378-5173
000151122 8564_ $$s4717585$$uhttps://zaguan.unizar.es/record/151122/files/texto_completo.pdf$$yVersión publicada
000151122 8564_ $$s2468962$$uhttps://zaguan.unizar.es/record/151122/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151122 909CO $$ooai:zaguan.unizar.es:151122$$particulos$$pdriver
000151122 951__ $$a2025-02-27-09:25:34
000151122 980__ $$aARTICLE