000151128 001__ 151128
000151128 005__ 20250227101503.0
000151128 0247_ $$2doi$$a10.3390/molecules26226891
000151128 0248_ $$2sideral$$a125763
000151128 037__ $$aART-2021-125763
000151128 041__ $$aeng
000151128 100__ $$aCanudo Barreras G.
000151128 245__ $$aSynthesis of new thiourea-metal complexes with promising anticancer properties
000151128 260__ $$c2021
000151128 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151128 5203_ $$aIn this work, two thiourea ligands bearing a phosphine group in one arm and in the other a phenyl group (T2) or 3, 5-di-CF3 substituted phenyl ring (T1) have been prepared and their coordination to Au and Ag has been studied. A different behavior is observed for gold complexes, a linear geometry with coordination only to the phosphorus atom or an equilibrium between the linear and three-coordinated species is present, whereas for silver complexes the coordination of the ligand as PˆS chelate is found. The thiourea ligands and their complexes were explored against different cancer cell lines (HeLa, A549, and Jurkat). The thiourea ligands do not exhibit relevant cytotoxicity in the tested cell lines and the coordination of a metal triggers excellent cytotoxic values in all cases. In general, data showed that gold complexes are more cytotoxic than the silver compounds with T1, in particular the complexes [AuT1(PPh3)]OTf, the bis(thiourea) [Au(T1)2 ]OTf and the gold-thiolate species [Au(SR)T1]. In contrast, with T2 better results are obtained with silver species [AgT1(PPh3)]OTf and the [Ag(T1)2 ]OTf. The role played by the ancillary ligand bound to the metal is important since it strongly affects the cytotoxic activity, being the bis(thiourea) complex the most active species. This study demonstrates that metal complexes derived from thiourea can be biologically active and these compounds are promising leads for further development as potential anticancer agents.
000151128 536__ $$9info:eu-repo/grantAgreement/ES/AEI/FEDER/CTQ2017-88091-P$$9info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21$$9info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/RED2018-102471-T
000151128 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000151128 590__ $$a4.927$$b2021
000151128 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b114 / 297 = 0.384$$c2021$$dQ2$$eT2
000151128 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b65 / 179 = 0.363$$c2021$$dQ2$$eT2
000151128 592__ $$a0.705$$b2021
000151128 593__ $$aAnalytical Chemistry$$c2021$$dQ1
000151128 593__ $$aDrug Discovery$$c2021$$dQ1
000151128 593__ $$aPharmaceutical Science$$c2021$$dQ1
000151128 593__ $$aMolecular Medicine$$c2021$$dQ1
000151128 593__ $$aOrganic Chemistry$$c2021$$dQ1
000151128 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000151128 594__ $$a5.9$$b2021
000151128 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151128 700__ $$aOrtego L.
000151128 700__ $$aIzaga, A.
000151128 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo Rubio I.$$uUniversidad de Zaragoza
000151128 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera R.
000151128 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno M.C.
000151128 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000151128 773__ $$g26, 22 (2021), 6891 [16 pp.]$$pMolecules (Basel, Online)$$tMolecules$$x1420-3049
000151128 8564_ $$s1539599$$uhttps://zaguan.unizar.es/record/151128/files/texto_completo.pdf$$yVersión publicada
000151128 8564_ $$s2714287$$uhttps://zaguan.unizar.es/record/151128/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151128 909CO $$ooai:zaguan.unizar.es:151128$$particulos$$pdriver
000151128 951__ $$a2025-02-27-09:25:46
000151128 980__ $$aARTICLE