Influencia del ácido tranexámico intraarticular sobre el ahorro de costes y los resultados funcionales precoces en artroplastia total de rodilla

Urgel Granados, A.C. ; Torres Campos, A. (Universidad de Zaragoza) ; Royo Agustín, M. ; Rillo Lázaro, A. ; Espallargas Donate, M.T. ; Castro Sauras, Á.

Resumen: Background and aim: Total knee arthroplasty (TKA) is a frequent intervention that can associate significant blood loss. There are several methods to avoid transfusions. One of the most relevant is tranexamic acid (TXA). Our purpose is to analyse the efficacy in terms of blood savings, transfusion needs, functional results, and cost-effectiveness of intra-articular (IA) administration in TKA. Materials and methods: We conducted a retrospective analysis of historical cohorts (75 patients each) between January 2015 and December 2016. We included 150 patients (59.3% women) with a mean age of 73.58 years. The intervention consisted of administering 2 g of IA TXA with a contact time of 30 minutes. Demographic data, preoperative haematological status, surgery data, estimated total blood loss (ETBL), need for transfusion, functional results, and cost analysis were collected. The level of statistical significance was p = 0, 05. Results: The incidence of transfusion was 17.33% in the control group and 5.33% in the TXA group (p = 0.039), with a relative risk reduction of 78.3%. The TXA cohort showed a reduction in ETBL (p < 0.0005), units transfused (p = 0.019) and length of stay (p = 0.004). All early functional parameters also improved, including a 10° improvement in both flexion and extension (p < 0.0005). The use of IA TXA resulted in savings of 337.78 € per patient. Conclusions: In our experience, the administration of IA TXA in TKA is a cost-effective and efficient measure in terms of blood savings and immediate postoperative functional improvement.

Idioma: Español

DOI: 10.1016/j.recot.2020.09.006

Año: 2021

Publicado en: Revista Espanola de Cirugia Ortopedica y Traumatologia 65, 4 (2021), 285-293
ISSN: 1888-4415

Factor impacto CITESCORE: 1.0 - Medicine (Q3)

Factor impacto SCIMAGO: 0.2 - Surgery (Q3) - Orthopedics and Sports Medicine (Q3)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Traumatología y Ortopedia (Dpto. Cirugía)