Decoupling manufacturing from application in additive manufactured antimicrobial materials

Wales , D.J. ; Miralles-Comins, S. ; Franco-Castillo, I. ; Cameron, J.M. ; Cao, Q. ; Karjalainen, E. ; Alves Fernandes, J. ; Newton, G.N. ; Mitchell, S.G. ; Sans, V.

Resumen: 3D printable materials based on polymeric ionic liquids (PILs) capable of controlling the synthesis and stabilisation of silver nanoparticles (AgNPs) and their synergistic antimicrobial activity are reported. The interaction of the ionic liquid moieties with the silver precursor enabled the controlled in situ formation and stabilisation of AgNPs via extended UV photoreduction after the printing process, thus demonstrating an effective decoupling of the device manufacturing from the on-demand generation of nanomaterials, which avoids the potential aging of the nanomaterials through oxidation. The printed devices showed a multi-functional and tuneable microbicidal activity against Gram positive (B. subtilis) and Gram negative (E. coli) bacteria and against the mould Aspergillus niger. While the polymeric material alone was found to be bacteriostatic, the AgNPs conferred bactericidal properties to the material. Combining PIL-based materials with functionalities, such as in situ and photoactivated on-demand fabricated antimicrobial AgNPs, provides a synergistic functionality that could be harnessed for a variety of applications, especially when coupled to the freedom of design inherent to additive manufacturing techniques.

Idioma: Inglés

DOI: 10.1039/d1bm00430a

Año: 2021

Publicado en: Biomaterials Science 9, 16 (2021), 5467-5476
ISSN: 2047-4830

Factor impacto JCR: 7.59 (2021)

Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 9 / 45 = 0.2 (2021) - Q1 - T1

Factor impacto CITESCORE: 9.9 - Materials Science (Q1) - Engineering (Q1)

Factor impacto SCIMAGO: 1.24 - Materials Science (miscellaneous) (Q1) - Biomedical Engineering (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E15-20R
Financiación: info:eu-repo/grantAgreement/ES/MCIU/PID2019-109333RB-I00

Tipo y forma: Article (Published version)