Mathematical Model of CAR T-Cell Therapy for a B-Cell Lymphoma Lymph Node

Sabir, Soukaina ; León-Triana, Odelaisy ; Serrano, Sergio (Universidad de Zaragoza) ; Barrio, Roberto (Universidad de Zaragoza) ; Pérez-García, Victor M.

Resumen: CAR T-cell therapies have demonstrated significant success in treating B-cell leukemia in children and young adults. However, their effectiveness in treating B-cell lymphomas has been limited in comparison to leukemia. In this paper we present a mathematical model that elucidates the dynamics of diffuse large B-cell lymphoma and CAR T-cells in a lymph node. The mathematical model aids in understanding the complex interplay between the cell populations involved and proposes ways to identify potential underlying dynamical causes of treatment failure. We also study the phenomenon of immunosuppression induced by tumor cells and theoretically demonstrate its impact on cell dynamics. Through the examination of various response scenarios, we underscore the significance of product characteristics in treatment outcomes.

Idioma: Inglés

DOI: 10.1007/s11538-025-01417-1

Año: 2025

Publicado en: BULLETIN OF MATHEMATICAL BIOLOGY 87, 3 (2025), 33
ISSN: 0092-8240

Financiación: info:eu-repo/grantAgreement/ES/DGA/E24-23R
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E24-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP94_21
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00
Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2022-142341OB-I00
Financiación: info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00

Tipo y forma: Article (Published version)

Área (Departamento): Área Matemática Aplicada (Dpto. Matemática Aplicada)