000152042 001__ 152042
000152042 005__ 20250326144155.0
000152042 0247_ $$2doi$$a10.1177/0300985821999322
000152042 0248_ $$2sideral$$a126623
000152042 037__ $$aART-2021-126623
000152042 041__ $$aeng
000152042 100__ $$aMicheloud J.F.
000152042 245__ $$aPhotosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
000152042 260__ $$c2021
000152042 5060_ $$aAccess copy available to the general public$$fUnrestricted
000152042 5203_ $$aFive adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 µg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.
000152042 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000152042 590__ $$a3.157$$b2021
000152042 591__ $$aVETERINARY SCIENCES$$b18 / 145 = 0.124$$c2021$$dQ1$$eT1
000152042 591__ $$aPATHOLOGY$$b40 / 77 = 0.519$$c2021$$dQ3$$eT2
000152042 592__ $$a0.768$$b2021
000152042 593__ $$aVeterinary (miscellaneous)$$c2021$$dQ1
000152042 594__ $$a4.3$$b2021
000152042 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000152042 700__ $$0(orcid)0000-0002-2053-9842$$aLuján L.$$uUniversidad de Zaragoza
000152042 700__ $$aColque-Caro L.A.
000152042 700__ $$aNúñez-Montoya S.C.
000152042 700__ $$aBarbeito C.G.
000152042 700__ $$aPortiansky E.L.
000152042 700__ $$aGimeno E.J.
000152042 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000152042 773__ $$g58, 3 (2021), 568-573$$pVet. pathol.$$tVeterinary Pathology$$x0300-9858
000152042 8564_ $$s840192$$uhttps://zaguan.unizar.es/record/152042/files/texto_completo.pdf$$yVersión publicada
000152042 8564_ $$s2675312$$uhttps://zaguan.unizar.es/record/152042/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000152042 909CO $$ooai:zaguan.unizar.es:152042$$particulos$$pdriver
000152042 951__ $$a2025-03-26-13:53:52
000152042 980__ $$aARTICLE